Tag Archives: Research

Doctors grow new trachea from patient’s own adult stem cells

From the Wall Street Journal.

Excerpt:

Doctors have replaced the cancer-stricken windpipe of a patient with an organ made in a lab, a landmark achievement for regenerative medicine. The patient no longer has cancer and is expected to have a normal life expectancy, doctors said.

[…]The windpipe is a hollow tube, about 4.5 inches long, leading to the lungs. A key part of it is a scaffold—which functions like a skeleton for the organ—consisting of tissues such as cartilage and muscle. As a first step, a team led by Alexander Seifalian of University College London used plastic materials and nanotechnology to make an artificial version of the scaffold in the lab. It was closely modeled on the shape and size of the Eritrean man’s windpipe.

Meanwhile, researchers at Harvard Bioscience Inc. of Holliston, Mass., made a bioreactor, a shoe-box-size device similar to a spinning rotisserie machine. The artificial scaffold was placed on the bioreactor, and stem cells extracted from the patient’s bone marrow were dripped onto the revolving scaffold for two days.

With the patient on the surgery table, Dr. Macchiarini and colleagues then added chemicals to the stem cells, persuading them to differentiate into tissue—such as bony cells—that make up the windpipe.

About 48 hours after the transplant, imaging and other studies showed appropriate cells in the process of populating the artificial windpipe, which had begun to function like a natural one. There was no rejection by the patient’s immune system, because the cells used to seed the artificial windpipe came from the patient’s own body.

Another success for ethical adult stem cell research.

Related posts

Should government recognize and legalize same-sex marriage?

Earlier in the week, I posted a case against same-sex marriage that was restricted to non-religious arguments. Here’s an article written by famous Christian apologist J Warner Wallace that does the same thing, but it is  packed with even more evidence than mine!

In his article, he considers the following questions:

  • What is the aim of the same-sex marriage movement?
  • What percentage of people are gay in the United States?
  • What is the role of government?
  • Why should government promote traditional marriage?
  • Are heterosexual and homosexual relationships the same with respect to domestic violence?
  • Are heterosexual and homosexual relationships the same with respect to healthiness?
  • Are heterosexual and homosexual relationships the same with respect to spousal fidelity?
  • Are heterosexual and homosexual relationships the same with respect to stability?
  • Does it matter to children whether their two biological parents raise them or not?

Here’s an excerpt:

It’s clear that that traditional heterosexual two parent family units are far more enduring, monogamous, non-abusive and healthy. On these standards alone, it’s reasonable for us to value and promote traditional two parent marriages as the ‘ideal’ form of family in our culture. But as it turns out, a number of studies confirm that two ‘biological’ parents are actually required if we want to best assure success and well-being in our children.

Many studies come to this conclusion, including studies that are conducted by liberal advocacy groups who also recognize the fact that “children do best when raised by their two married biological parents…” (Mary Parke, “Are Married Parents Really Better for Children?”, Center for Law and Social Policy Policy Brief, May 2003, p.1). This reality is confirmed by a number of additional studies demonstrating that “an extensive body of research tells us that children do best when they grow up with both biological parents…” (Kristin Anderson Moore, et al., “Marriage From a Child’s Perspective: How Does Family Structure Affect Children, and What Can We Do about It?”, Child Trends Research Brief, June 2002, p.1).

We know, for example, that children raised in two biological parent families are far less likely to become sexually active at a young age compared to every other form of family unit, including stepfamilies. (Dawn Upchurch, et al., “Neighborhood and Family Contexts of Adolescent Sexual Activity”, Journal of Marriage and the Family, 61, 1999, 920-930). Children who are not living with both biological parents are 50 to 150% more likely to abuse drugs that kids who are raised in other types of family units, including stepfamilies like those formed in same sex unions. (Substance Abuse and Mental Health Services Administration, “The Relationship Between Family Structure and Adolescent Substance Use”, Rockville, MD, National Clearinghouse for Alcohol and Drug Information, 1996).

In a similar way, studies indicate that “children residing in households with adults unrelated to them were 8 times more likely to die of maltreatment than children in households with 2 biological parents. Risk of maltreatment death was elevated for children residing with step, foster, or adoptive parents.” (Michael Stiffman, et al., “Household Composition and Risk of Fatal Child Maltreatment,” Pediatrics, 109, 2002, pp.615-621). Over and over again, studies confirm the same reality: children do better when raised not only in two parent family units, but in two biological parent family units!

This conclusion is not limited to heterosexual studies. Even those who advocate and support same sex parenting recognize that there are inherent difficulties for children raised n these settings. The homosexual parenting literature continues to recognize this:

“The Lesbian and Gay Parenting Handbook: Creating and Raising Our Families” (April Martin):

“Some children do express an intense longing for the other biological parent, talking about it frequently and emotionally…. Adolescents take particular interest in both their heredity and in gender-specific role models.”

“The Lesbian Parenting Book: A Guide to Creating Families and Raising Children” (D. Merilee Clunis, G. Dorsey Green):

“It is very normal for children to long about and ask for a father…. It is natural to feel defensive when your child longs for a father. We encourage you to remain patient while she asks questions, sorts out information and comes to terms without knowing her father’s identity, or not having her biological father in her life. She needs to do it…. [Artificially Inseminated] children of lesbian parents may grieve never knowing their biological father.”

“Gay Men Choosing Parenthood” (Gerald P. Mallon):

“(The majority of children being raised in gay male households) sometimes verbalized a desire for a mother at one time or another.”

“For Lesbian Parents: Your Guide to Helping Your Family Grow Up Happy, Healthy, and Proud” (Suzanne M. Johnson, Elizabeth O’Connor):

“(Lesbian mothers should ask their daughters) if it’s hard sometimes not having a father. Let her know that you understand that sometimes it is hard.”

Please consider giving this article a read. It is very comprehensive, and cites a huge number of sources. I think that this topic mattered a lot more to the author than it did to me. I grew up in a marriage home and my parents are still married. I only write about the issues of single motherhood, divorce and same-sex marriage because I  have friends in these situations, and because I have read the research. But J Warner Wallace grew up in a single parent home. So he is writing about this topic based on his personal experience.

Further study

For a more academic case against SSM, see this peer-reviewed paper on traditional marriage and same-sex marriage, authored by two guys from Princeton University and one guy from the University of Notredame. One of those guys is the famous Robert P. George. For some simple, practical tips on defending traditional marriage, check out this tip sheet from the National Organization for Marriage.

You can also watch the videos from a formal academic debate on same-sex marriage held at the University of Central Florida, featuring Dr. Michael Brown. Dr. Jennifer Roback Morse also debated same-sex marriage at Columbia University in a formal academic debate. You can see her give a lecture on same-sex marriage at Houston Baptist University here, as well.

Protein binding: by chance or intelligent design?

Dr. Fazale Rana has this interesting post up on protein binding at Reasons to Believe.

Excerpt:

Nobody likes getting the flu. In fact, the influenza virus represents a serious health challenge. For most people it causes a few days of misery, but tragically for others, it takes their lives.

Biomedical researchers are looking for ways to develop therapies against the strains of the influenza virus that avoid destruction by the immune system or fail to respond to antiviral drugs. Recently scientists from the University of Washington and The Scripps Institute made progress toward this end. They designed novel proteins from scratch that bind to the stem region of hemagglutinin, a viral protein that plays a central role in the infection process.1 The hope is that the new proteins will have therapeutic use and also help with diagnosis.

This advance has obvious biomedical importance. It also contributes toward understanding the fundamental nature of protein-protein interactions (PPIs), and with this insight comes powerful new evidence that life stems from a Creator.

Often, in order to carry out their function, proteins must interact and bind in a highly specific manner with other proteins. These PPIs are selective. If the wrong proteins bind to each other, the interaction is of no use to the cell.

A large and varied population of proteins crowds the cell’s interior. Even the simplest bacterium harbors several thousand different types of proteins, along with numerous copies of the other biomolecules inside it. The jam-packed environment complicates things. Proteins are more likely to encounter the “wrong” partners than the ones they are designed to interact with.

Biochemists are currently working to understand the specificity of PPIs and how proteins avoid unintended interactions. As it turns out, protein surfaces are carefully structured to allow strong interactions between protein pairs while minimizing the strength of the unwanted interactions. Recent work by Harvard scientists indicates that the concentration of PPI-participating proteins in the cell is also designed carefully.

In other words, protein structure and concentrations have to be precisely regulated to promote the PPIs critical for life.

The rest of the article talks about all the intricate and cutting-edge engineering and computation done by the scientists to create a situation where the proteins could bind, and then ends with this:

When considering this study, it is remarkable to note how much effort it took to design a protein that binds to a specific location on the hemagglutinin molecule. As biochemists Bryan Der and Brian Kuhlman point out while commenting on this work, the design of these proteins required:

…cutting-edge software developed by ~20 groups worldwide and 100,000 hours of highly parallel computing time. It also involved using a technique known as yeast display to screen candidate proteins and select those with high binding affinities, as well as x-ray crystallography to validate designs.2

If it takes this much work and intellectual input to create a single protein from scratch, is it really reasonable to think that undirected evolutionary processes could accomplish this task routinely?

If you have to involve human intelligence to this degree, then I think that the best explanation is intelligent design.