Tag Archives: Peer-Review

News

Study confirms that predictions about junk DNA by materialists are false

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First, let’s see what Darwinian evolutionists predict about junk DNA, before we look at what the experiments show.

Here’s biologist John Timmer to explain the orthodox Darwinian view of DNA from 2007:

Personally, I fall into the “it’s all junk” end of the spectrum. If almost all of these sequences are not conserved by evolution, and we haven’t found a function for any of them yet, it’s hard to see how the “none of it’s junk” view can be maintained. There’s also an absence of support for the intervening view, again because of a lack of evidence for actual utility. The genomes of closely related species have revealed very few genes added from non-coding DNA, and all of the structural RNA we’ve found has very specific sequence requirements. The all-junk view, in contrast, is consistent with current data.

Got that? According to Darwinists, DNA is almost entirely junk – this is what is consistent with the view that creatures have evolved through a process of random mutation and selection. The estimates that I’ve seen from evolutionary biologists range from 95% to 99% junk. Now let’s compare the religion with science, and separate mythology from reality.

Now let’s compare that with intelligent design theorist William Dembski’s view of “junk” DNA, from 1998:

Even if we have a reliable criterion for detecting design, and even if that criterion tells us that biological systems are designed, it seems that determining a biological system to be designed is akin to shrugging our shoulders and saying God did it. The fear is that admitting design as an explanation will stifle scientific inquiry, that scientists will stop investigating difficult problems because they have a sufficient explanation already.

But design is not a science stopper. Indeed, design can foster inquiry where traditional evolutionary approaches obstruct it. Consider the term “junk DNA.” Implicit in this term is the view that because the genome of an organism has been cobbled together through a long, undirected evolutionary process, the genome is a patchwork of which only limited portions are essential to the organism. Thus on an evolutionary view we expect a lot of useless DNA. If, on the other hand, organisms are designed, we expect DNA, as much as possible, to exhibit function. And indeed, the most recent findings suggest that designating DNA as “junk” merely cloaks our current lack of knowledge about function… Design encourages scientists to look for function where evolution discourages it.

Now let’s look at the experimental evidence and see whose prediction was proven right by the progress of science.

Science Daily reports on a recent study that confirms the previous study that falsified Darwinian predictions about junk DNA.

Excerpt:

Researchers from the Gene and Stem Cell Therapy Program at Sydney’s Centenary Institute have confirmed that, far from being “junk,” the 97 per cent of human DNA that does not encode instructions for making proteins can play a significant role in controlling cell development.

[…]Using the latest gene sequencing techniques and sophisticated computer analysis, a research group led by Professor John Rasko AO and including Centenary’s Head of Bioinformatics, Dr William Ritchie, has shown how particular white blood cells use non-coding DNA to regulate the activity of a group of genes that determines their shape and function. The work is published today in the scientific journalCell.

“This discovery, involving what was previously referred to as “junk,” opens up a new level of gene expression control that could also play a role in the development of many other tissue types,” Rasko says. “Our observations were quite surprising and they open entirely new avenues for potential treatments in diverse diseases including cancers and leukemias.”

Now, this is yet another falsification of Darwinism, to go with the other papers that I keep posting about new research that falsifies Darwinism. How many papers do we need to falsify Darwinism? I think if you are in an argument over Darwinism, and you produce these articles, then you win, so long as the other person cannot produce anything. It’s also a good idea to couple these pieces of evidence with a positive case for intelligent causes operating during the origin of life and the Cambrian explosion.

Commentary

The Economist: some problems with the peer-review process

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From The Economist, of all places.

Excerpt:

The idea that the same experiments always get the same results, no matter who performs them, is one of the cornerstones of science’s claim to objective truth. If a systematic campaign of replication does not lead to the same results, then either the original research is flawed (as the replicators claim) or the replications are (as many of the original researchers on priming contend). Either way, something is awry.

It is tempting to see the priming fracas as an isolated case in an area of science—psychology—easily marginalised as soft and wayward. But irreproducibility is much more widespread. A few years ago scientists at Amgen, an American drug company, tried to replicate 53 studies that they considered landmarks in the basic science of cancer, often co-operating closely with the original researchers to ensure that their experimental technique matched the one used first time round. According to a piece they wrote last year in Nature, a leading scientific journal, they were able to reproduce the original results in just six. Months earlier Florian Prinz and his colleagues at Bayer HealthCare, a German pharmaceutical giant, reported in Nature Reviews Drug Discovery, a sister journal, that they had successfully reproduced the published results in just a quarter of 67 seminal studies.

Let’s take a look at some of the problems from the article.

Problems with researcher bias:

Other data-heavy disciplines face similar challenges. Models which can be “tuned” in many different ways give researchers more scope to perceive a pattern where none exists. According to some estimates, three-quarters of published scientific papers in the field of machine learning are bunk because of this “overfitting”, says Sandy Pentland, a computer scientist at the Massachusetts Institute of Technology.

Problems with journal referees:

Another experiment at the BMJ showed that reviewers did no better when more clearly instructed on the problems they might encounter. They also seem to get worse with experience. Charles McCulloch and Michael Callaham, of the University of California, San Francisco, looked at how 1,500 referees were rated by editors at leading journals over a 14-year period and found that 92% showed a slow but steady drop in their scores.

As well as not spotting things they ought to spot, there is a lot that peer reviewers do not even try to check. They do not typically re-analyse the data presented from scratch, contenting themselves with a sense that the authors’ analysis is properly conceived. And they cannot be expected to spot deliberate falsifications if they are carried out with a modicum of subtlety.

Problems with fraud:

Fraud is very likely second to incompetence in generating erroneous results, though it is hard to tell for certain. Dr Fanelli has looked at 21 different surveys of academics (mostly in the biomedical sciences but also in civil engineering, chemistry and economics) carried out between 1987 and 2008. Only 2% of respondents admitted falsifying or fabricating data, but 28% of respondents claimed to know of colleagues who engaged in questionable research practices.

Problems releasing data:

Reproducing research done by others often requires access to their original methods and data. A study published last month inPeerJ by Melissa Haendel, of the Oregon Health and Science University, and colleagues found that more than half of 238 biomedical papers published in 84 journals failed to identify all the resources (such as chemical reagents) necessary to reproduce the results. On data, Christine Laine, the editor of the Annals of Internal Medicine, told the peer-review congress in Chicago that five years ago about 60% of researchers said they would share their raw data if asked; now just 45% do. Journals’ growing insistence that at least some raw data be made available seems to count for little: a recent review by Dr Ioannidis which showed that only 143 of 351 randomly selected papers published in the world’s 50 leading journals and covered by some data-sharing policy actually complied.

Critics of global warming have had problems getting at data before, as Nature reported here:

Since 2002, McIntyre has repeatedly asked Phil Jones, director of CRU, for access to the HadCRU data. Although the data are made available in a processed gridded format that shows the global temperature trend, the raw station data are currently restricted to academics. While Jones has made data available to some academics, he has refused to supply McIntyre with the data. Between 24 July and 29 July of this year, CRUreceived 58 freedom of information act requests from McIntyre and people affiliated with Climate Audit. In the past month, the UK Met Office, which receives a cleaned-up version of the raw data from CRU, has received ten requests of its own.

Why would scientists hide their data? Well, recall that the Climategate scandal resulted from unauthorized release of the code used to generate the data used to promote global warming alarmism. The leaked code showed that the scientists had been generating faked data using a “fudge factor”.

Elsewhere, leaked e-mailed from global warmists revealed that they do indeed suppress articles that are critical of global warming alarmism:

As noted previously, the Climategate letters and documents show Jones and the Team using the peer review process to prevent publication of adverse papers, while giving softball reviews to friends and associates in situations fraught with conflict of interest. Today I’ll report on the spectacle of Jones reviewing a submission by Mann et al.

Let’s recall some of the reviews of articles daring to criticize CRU or dendro:

I am really sorry but I have to nag about that review – Confidentially I now need a hard and if required extensive case for rejecting (Briffa to Cook)
…
If published as is, this paper could really do some damage. It is also an ugly paper to review because it is rather mathematical, with a lot of Box-Jenkins stuff in it. It won’t be easy to dismiss out of hand as the math appears to be correct theoretically, (Cook to Briffa)
…
Recently rejected two papers (one for JGR and for GRL) from people saying CRU has it wrong over Siberia. Went to town in both reviews, hopefully successfully. (Jones to Mann)

One last quote from the Economist article. One researcher submitted a completely bogus paper to many journals, and many of them accepted it:

John Bohannon, a biologist at Harvard, recently submitted a pseudonymous paper on the effects of a chemical derived from lichen on cancer cells to 304 journals describing themselves as using peer review. An unusual move; but it was an unusual paper, concocted wholesale and stuffed with clangers in study design, analysis and interpretation of results. Receiving this dog’s dinner from a fictitious researcher at a made up university, 157 of the journals accepted it for publication.

Dr Bohannon’s sting was directed at the lower tier of academic journals. But in a classic 1998 study Fiona Godlee, editor of the prestigious British Medical Journal, sent an article containing eight deliberate mistakes in study design, analysis and interpretation to more than 200 of the BMJ’s regular reviewers. Not one picked out all the mistakes. On average, they reported fewer than two; some did not spot any.

The Economist article did not go into the problem of bias due to worldview presuppositions, though. So let me say something about that.

A while back Casey Luskin posted a list of problems with peer review.

Here was one that stuck out to me:

Point 5: The peer-review system is often biased against non-majority viewpoints.
The peer-review system is largely devoted to maintaining the status quo. As a new scientific theory that challenges much conventional wisdom, intelligent design faces political opposition that has nothing to do with the evidence. In one case, pro-ID biochemist Michael Behe submitted an article for publication in a scientific journal but was told it could not be published because “your unorthodox theory would have to displace something that would be extending the current paradigm.” Denyse O’Leary puts it this way: “The overwhelming flaw in the traditional peer review system is that it listed so heavily toward consensus that it showed little tolerance for genuinely new findings and interpretations.”

Recently, I summarized a podcast on the reviewer bias problem featuring physcist Frank Tipler. His concern in that podcast was that peer-review would suppress new ideas, even if they were correct. He gave examples of this happening. Even a paper by Albert Einstein was rejected by a peer-reviewed journal. Elsewhere, Tipler was explicitly told to remove positive references to intelligent design in order to get his papers published. Tipler’s advice was for people with new ideas to bypass the peer-reviewed journal system entirely.

Speaking about the need to bypass peer-review, you might remember that the Darwinian hierarchy is not afraid to have people sanctioned if they criticize Darwinism in peer-reviewed literature.

Recall the case of Richard Sternberg.

Excerpt:

In 2004, in my capacity as editor of The Proceedings of the Biological Society of Washington, I authorized “The Origin of Biological Information and the Higher Taxonomic Categories” by Dr. Stephen Meyer to be published in the journal after passing peer-review. Because Dr. Meyer’s article presented scientific evidence for intelligent design in biology, I faced retaliation, defamation, harassment, and a hostile work environment at the Smithsonian’s National Museum of Natural History that was designed to force me out as a Research Associate there. These actions were taken by federal government employees acting in concert with an outside advocacy group, the National Center for Science Education. Efforts were also made to get me fired from my job as a staff scientist at the National Center for Biotechnology Information.

So those are some of the issues to consider when thinking about the peer-review process. My view is that peer-reviewed evidence does count for something in a debate situation, but as you can see from the Economist article, it may not count for as much as it used to. I think my view of science in general has been harmed by what I saw from physicist Lawrence Krauss in his third debate with William Lane Craig. If a scientist can misrepresent another scientist and not get fired by his employer, then I think we really need to be careful about the level of honesty in the academy.

News

Stephen C. Meyer and Peter Atkins debate intelligent design

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This dialog occurred in 2010 on the Unbelievable radio show.

I made a rough transcript, so please see below for that.

The MP3 file is here. (60 minutes)

Details:

The documentary film “Expelled” is presented by US Actor Ben Stein and makes the case that scientists who question Darwinian orthodoxy and support Intelligent Design are being “expelled” from academia.

As the UK edition of the DVD is released we ask “Is freedom of thought at stake or is Intelligent Design out of bounds when it comes to biological science?”

Stephen C Meyer is co founder of the Discovery Institute in the USA and a major proponent of Intelligent Design.

Peter Atkins is Professor of Chemistry at Oxford University and an outspoken atheist.

They both feature in “Expelled” and join Justin to debate the pros and cons of Intelligent Design theory.

Mark Haville who is bringing the film to the UK also joins the discussion.

Note: The transcript below is quite snarky and may include paraphrases of Dr. Atkins for the sake of humor.

My rough transcript of the Meyer-Atkins debate

Stephen Meyer:
– started researching on ID while doing his PhD at Cambridge
– the question is whether the information-bearing properties in DNA require a designer
– what cause is adequate to explain the digital code that in the simplest living cell
– alternative explanations like self-organization and RNA-first have failed
– so the best explanation for functional sequences of parts is an intelligent designer
– Darwinists have responded to this argument with insults and suppression of dissent

Peter Atkins:
– intelligent design is creationism
– there is no science at all in it
– information can emerge without an intelligent designer
– structures emerge spontaneously, no agent is needed to generate the structure
– information in DNA is also a structure

Stephen Meyer:
– structure and information are two different things
– many structures emerge spontaneously
– structure may be like the vortex that occurs when water goes down a drain

Peter Atkins:
– the vortex is information

Stephen Meyer:
– structures are different from functionally-specified digital information
– in DNA, there is a 4-digit alphabet that is used to create code sequences
– the thing to be explained is where do the functional sequences come from

Peter Atkins:
– information can grow without an agent
– the second law of thermodynamics
– the universe is falling into disorder
– but there are local abatements of chaos that create information
– evolution can cause the amount of information to grow

Stephen Meyer:
– that’s just an assertion
– I agree that energy flow through a system can produce spontaneous order
– but spontaneous order is not the same thing as information

Peter Atkins:
– spontaneous order is the same as information

Stephen Meyer:
– it’s not order that needs to be explained it’s specified complexity

Peter Atkins:
– what do you mean by specified complexity?

Stephen Meyer:
– the chemical bonds that connect to each letter do not determine the letter
– the chemical bonding sites will accept any letter as easily as any other
– any one of the 4 bases (letters) can attach at any place along the backbone

Peter Atkins:
– the selection of which letter comes next is determined by evolution

Stephen Meyer:
– that is just an assertion
– there is no physical process that sequences the letters to have a function

Peter Atkins:
– do you believe in evolution? YES OR NO!

Mark Haville:
– for him to answer the question you have to define the word
– do you mean macro or micro? biological or stellar? directed or undirected?

Peter Atkins:
– undirected molecules to man evolution by natural processes

Stephen Meyer:
– but even Dawkins doesn’t believe in evolution then
– you’re including the origin of life from non-living matter in evolution
– Dawkins says that there is no known naturalistic explanation for that

Mark Haville:
– you need to define your terms

[They discuss of the movie Expelled and the case of Richard Sternberg]

Stephen Meyer:
– the problem is people don’t want to talk about the science
– they denounce dissent as unscientific
– they will not debate about whther natural causes can explain the information
– I want to talk about the science

Peter Atkins:
– ID people raise interesting questions for naturalists to work on
– but you want to tell us what the answer is (intelligence) before we begin
– you start from the idea that an intelligence was involved

Justin Brierley:
– but you start with the idea that natural mechanisms can explain everything!

Stephen Meyer:
– for Dr. Atkins, only explanations based on material processes are valid

Peter Atkins:
– that is correct

Stephen Meyer:
– but we think that the activities of mind can explain some effects
– e.g. – the best explanation of the Rosetta stone is a mind

Peter Atkins:
– but we naturalists think of minds as material as well

Stephen Meyer:
– that’s a materialist pre-supposition on your part
– we would have to have a debate about mind and body

Mark Haville:
– I think that the materialist position is socially dangerous
– the problem with naturalism is that it is an ideology
– the ideology pushes absurdities, e.g. – the universe came from nothing uncaused
– and naturalists exert power over others to force them to believe nonsense

Stephen Meyer:
– science progresses as the result of scientists disagreeing
– both sides agree to the facts
– the debate is about the interpretation of those facts
– and one side is being ruled out a priori based on the pre-supposition of materialism

Peter Atkins:
– why do you say that an intelligence is involved in DNA but not general relativity

Stephen Meyer:
– it is always logically possible that intelligence can be invlved in any effect
– the main thing is that explanations based on intelligence should not be ruled out

Peter Atkins:
= well you can’t appeal to any non-material process in expaining anything
– those are the rules

Moderator:
– what does intelligent design have to do with religion?

Stephen Meyer:
– creationism is about understanding the istory of life using the Bible
– intelligent design is about using the same method of inquiry as Darwin
– we know that information arises from intelligent causes
– humans create information all the time by using intelligence to sequence parts

Moderator:
– are intelligent design proponents disreputable?

Stephen Meyer:
– what’s disreputable is shutting down debate by setting arbitrary rules

Peter Atkins:
– we are both interested in the same questions

Moderator:
– why won’t you let Stephen publish his papers then?

Peter Atkins:
– because it breaks the pre-suppositions of naturalism and materialism

Stephen Meyer:
– you’re shutting down inquiry by using an arbitrary definition of science

Mark Haville:
– we need to define the word science
– science should be based on what we can observe empirically
– we can observe micro-evolution empirically
– but Darwinism goes beyond what is observable to postulate macro-evolution

Peter Atkins:
– but paleobiology is replete with evidence

Stephen Meyer:
– paleobiology uses a method of inference that I think is valid
– but intelligent design uses the same mode of reasoning which is also valid

Peter Atkins:
= you’re intellectually lazy
– we’re smart, we’re using our brains

Moderator:
– you’re saying that appeals to intelligent causes ends science?
– is ID the view that some things are too complex to be explained with naturalism?

Peter Atkins:
– yes, and to teach children that materialism is false is child abuse

Stephen Meyer:
– let’s drop the insults and the rhetoric and focus on the arguments
– the ID argument is not based on what we don’t know, it’s based on what we DO know
– first, we can ask what undirected natural processes can and cannot do
– second, we can ask what we know about intelligent causes from our own experience
– what we do know seems to me to require an intelligent agent as a cause

Peter Atkins:
– GOD! Do you mean God!? Do you mean God!?

Stephen Meyer:
– I personally mean God, but all that the arguments proves is a generic intelligent cause
– and I am using the same method of investigation that Darwin used to get there
– what we know from our experience is that a mind is needed to create information

Peter Atkins:
– NONSENSE! ABSOLUTE NONSENSE!

Stephen Meyer:
– in my book, I list 10 predictions made by ID, so it’s not a science-stopper
– furthermore, the enterprise of science began with th goal of understanding God
– consider the earliest scientists, people like James Boyler and Johannes Kepler

Peter Atkins:
– that was 300 years ago, we’ve moved on

Mark Haville:
– what about Max Planck then?

Stephen Meyer:
– how about James Clark Maxwell?

Mark Haville:
– we need to focus on the facts

Peter Atkins:
– what do you mean by the facts?

Mark Haville:
– well the fact is that Darwinism has no mechanism to produce new information

Peter Atkins:
– well copying errors introduces beneficial mutations

Stephen Meyer:
– let’s focus on where we get the first information from the simplest organism
– you can’t account for the first organism by appealing to copying errors
– to add functionality to a program, you need new lines codes from an intelligence
– once you have life, you can generate some new information
– but you can’t generate macro-evolution either

Peter Atkins:
– if we give you your explanation for teh origin of life, will you give this up

Stephen Meyer:
– of course! I’m a former theistic evolutionist
– but right now the evidence is not there for it
– we have to decide these questions based on what we see with our own eyes today

Peter Atkins:
– but I pre-suppose materialism as the starting point of all explanations
– you’re just intellectually lazy to abandon my pre-supposition

Stephen Meyer:
– why is it is less intellectually lazy to insist that materialism is true
– we are making plenty of predictions, and isn’t that what science is about?
– consider Junk DNA – you guys said it had no use
– now we know it has a use

Peter Atkins:
– naturalists were open to the idea that junk DNA might have a use before ID

Moderator:
– Dr. Meyer, what about the wall that locks out intelligence as an explanation?

Stephen Meyer:
– if these are interesting questions, then we should allow freedom of inquiry
– that’s how science advances

Peter Atkins:
– for all their science-talk really they are just saying God did it
– people who don’t agree with me are not using their brains, like I do
– to give up on my pre-supposition of materialism is a denial of humanity

Mark Haville:
– there are important issues that are affected by our view of origins
– everyone who hasn’t seen Expelled movie should definitely see it