Tag Archives: Life

Doug Axe publishes a new peer-reviewed paper on protein folding

A new podcast from ID the Future is worth listening to.

Participants

  • Jay Richards, Director of Research at the CRSC, (Discovery Institute)
  • Doug Axe, Director of the Biologic Institute

The MP3 file is here.

Topics

  • the new BIO-Complexity peer-reviewed journal
  • new peer-reviewed paper challenges Darwinian account of protein folding
  • proteins are found in every living system
  • a protein is a chain of parts called amino acids
  • there are 20 amino acids used in living systems
  • it’s like a 20-letter alphabet used to make sentences (proteins)
  • if the sequence is just right, it folds up and has a function
  • the information about the functional sequences is in the genome
  • the “protein fold” is the 3D shape that a functional protein takes on
  • the folding problem is good because you can TEST Darwinian mechanisms
  • the problem is simple enough to be tested rigorously in a lab
  • Question: how easy is it to create a sequence that folds?
  • English is a good analogy to the problem of protein folding
  • you have a long string of characters (e.g. – 200 letters)
  • each “letter” can be one of 20 amino acids
  • if you assign the letters randomly, you almost always get gibberish
  • there are tons of possible sequences of different letters
  • it’s like a 200 digit slot machine with each digit having 20 possibilities!
  • the number of sequences that would actually make sense is tiny
  • protein folding is the same
  • Doug’s paper assesses how many “tries” could have been attempted
  • Doug’s paper calculates the total number of possibilities
  • cells have arrived a large number of functional sequences
  • but only a small number of the total possibilities could have been tried
  • this is called the “sampling problem”
  • there isn’t enough time to test all of the possibilities (see previous paper below)
  • how did living systems arrive at the functional sequences so quickly?
  • there are some possible naturalistic scenarios for solving the problem
  • Doug’s new paper shows that none of the naturalistic explanations work
  • the only explanation left is that an intelligence sequenced the amino acids
  • it is identical to the way that I can sequence letters to make this post

A picture is worth a thousand words

Here’s a video clip from the DVD Darwin’s Dilemma showing the process:

If you would like to know more about Darwin’s Dilemma, you can read Brian Auten’s review of Darwin’s Dilemma.

Who are these guys?

I wrote a post before on Doug Axe’s previous publications in the Journal of Molecular Biology, where he researched how many of the possible sequences of amino acids have biological function. His PhD is from Caltech, and his post-doctoral research on proteins was conducted at Cambridge University.

Jay Richards is a Senior Fellow of the Discovery Institute and a Contributing Editor of The American at the American Enterprise Institute. In recent years he has been a Visiting Fellow at the Heritage Foundation, and a Research Fellow and Director of Acton Media at the Acton Institute. His PhD is from Princeton University.

Related posts

William Dembski discusses irreducible complexity and co-option

William Dembski explains what the debate on origins is really about.

About the speaker:

Dr. Dembski has taught at Northwestern University, the University of Notre Dame, and the University of Dallas. He has done postdoctoral work in mathematics at MIT, in physics at the University of Chicago, and in computer science at Princeton University. A graduate of the University of Illinois at Chicago where he earned a B.A. in psychology, an M.S. in statistics, and a Ph.D. in philosophy, he also received a doctorate in mathematics from the University of Chicago in 1988 and a master of divinity degree from Princeton Theological Seminary in 1996. He has held National Science Foundation graduate and postdoctoral fellowships.

The lecture:

Part 1:

Part 2:

Part 3:

Summary (snark is in italics)

What is evolution:

  • Is it enough for Christian students to just retain their faith in college?
  • Or should Christian students seek to transform their universities?
  • The word “evolution” refers to a unguided, purposeless, undirected process
  • Living organisms are not designed, they just appear to be designed
  • Therefore, it is an atheistic theory – there is NO ROOM for God
  • Random variations and natural selection can do the creating of life without God
  • Nothing about evolution suggest that God had anything to do with it

The appearance of design:

  • The cell is a nano-engineered information processing system.
  • The cell has engineering, e.g. – signal transduction, message passing, etc.
  • There are molecular machines similar to man-made machines, but less efficient
  • E.g. – the bacterial flagellum which has 40 parts
  • These molecular machines have minimal complexity – all the parts are needed
  • can’t build a molecular machine step-by-step – all the parts must be present and integrated

How does evolution try to explain molecular machines:

  • The standard naturalistic response is “co-option”
  • Each intermediate step has pieces that are used for other purposes
  • I.e. – Subsets of the parts can have different functions
  • For example, a subset of the bacterial flagellum can be used as a syringe
  • The subset, called the Type-3 secretory system, has only 13 parts
  • The problem is that evolutionists don’t show all the steps, and all the functions
  • For this to be a good response, you need a smooth path from 1 part up to 40
  • Each step of the path has to have a working system with a different function
  • But the atheists don’t have the path, or the intermediate functions
  • It’s like arguing that you can walk from Seattle to Tokyo via the Hawaiian islands

Is the bacterial flagellum a cherry-picked example?

  • There are no detailed molecular pathways for any biochemical systems in the cell
  • The atheistic response is to speculate that pathways will be found as science progresses
  • The pathways are unobservable entities, just like the multiverse and the Cambrian precursors

Where does the machinery to create proteins come from?

  • The molecular machines are composed of proteins
  • The proteins are manufactured by copying protein-building instructions from the DNA
  • The instructions are carried to the build site by messenger RNA
  • The build site is called a ribosome
  • The DNA requires proteins to build, so there is a chicken-and-egg problem
  • The problem is that protein transcription systems require everything in place
  • There is no materialistic theory about how to build this step-by-step

So what do the molecular machines tell us about how life began?

  • The problem of the origin of life is the problem of the origin of information
  • What needs to be explained are the functional sequences of parts
  • The sequences are identical to sequences of letters that make sense
  • The atheist has to say that material processes can create the information
  • The problem of finding sequences of amino acids or proteins is a search problem
  • A blind search of the space of possible sequences is not efficient
  • even with lots time, parts and trials, you can’t converge on functional proteins
  • information is required and the only known producer of information is a mind

Bill is one of my favorite people. He’s smarter than practically all of the atheists who dominate the universities. But because he is an outspoken Christian, he never gets the recognition he deserves. He just keeps plugging away on his research. He doesn’t make excuses.

What is intelligent design?

Related DVDs

Illustra also made two other great DVDs on intelligent design. The first two DVDs “Unlocking the Mystery of Life” and “The Privileged Planet” are must-buys, but you can watch them on youtube if you want, for free.

Here are the 2 playlists:

I also recommend Coldwater Media’s “Icons of Evolution”. All three of these are on sale from Amazon.com.

Related posts

Guillermo Gonzalez lectures at UC Davis on the requirements for life

The 5 video clips that make up the full lecture.

The playlist for all 5 clips is here.

About the speaker

Guillermo Gonzalez is an Associate Professor of Physics at Grove City College. He received his Ph.D. in Astronomy in 1993 from the University of Washington. He has done post-doctoral work at the University of Texas, Austin and at the University of Washington and has received fellowships, grants and awards from such institutions as NASA, the University of Washington, the Templeton Foundation, Sigma Xi (scientific research society) and the National Science Foundation.

Learn more about the speaker here.

The lecture

Here’s part 1 of 5:

Habitability topics:

  • What is the Copernican Principle?
  • Is the Earth’s suitability for hosting life rare in the universe?
  • Does the Earth have to be the center of the universe to be special?
  • How similar to the Earth does a planet have to be to support life?
  • What is the definition of life?
  • What are the three minimal requirements for life of any kind?
  • Requirement 1: A molecule that can store information (carbon)
  • Requirement 2: A medium in which chemicals can interact (liquid water)
  • Requirement 3: A diverse set of chemical elements
  • What is the best environment for life to exist?
  • Our place in the solar system: the circumstellar habitable zone
  • Our place in the galaxy: the galactic habitable zones
  • Our time in the universe’s history: the cosmic habitable age
  • Other habitability requirements (e.g. – metal-rich star, massive moon, etc.)
  • The orchestration needed to create a habitable planet
  • How different factors depend on one another through time
  • How tweaking one factor can adversely affect other factors
  • How many possible places are there in the universe where life could emerge?
  • Given these probabilistic resources, should we expect that there is life elsewhere?
  • How to calculate probabilities using the “Product Rule”
  • Can we infer that there is a Designer just because life is rare? Or do we need more?

The corelation between habitability and measurability.

  • Are the habitable places in the universe also the best places to do science?
  • Do the factors that make Earth habitable also make it good for doing science?
  • Some places and times in the history of the universe are more habitable than others
  • Those exact places and times also allow us to make scientific discoveries
  • Observing solar eclipses and structure of our star, the Sun
  • Observing stars and galaxies
  • Observing the cosmic microwave background radiation
  • Observing the acceleration of the universe caused by dark matter and energy
  • Observing the abundances of light elements like helium of hydrogen
  • These observations support the big bang and fine-tuning arguments for God’s existence
  • It is exactly like placing observatories on the tops of mountains
  • There are observers existing in the best places to observe things
  • This is EXACTLY how the universe has been designed for making scientific discoveries

This lecture was delivered by Guillermo Gonzalez in 2007 at the University of California at Davis.

What is intelligent design?

Related DVDs

Illustra also made two other great DVDs on intelligent design. The first two DVDs “Unlocking the Mystery of Life” and “The Privileged Planet” are must-buys, but you can watch them on youtube if you want, for free.

Here are the 2 playlists:

I also recommend Coldwater Media’s “Icons of Evolution”. All three of these are on sale from Amazon.com.

Related posts