Tag Archives: Reason

News

Doug Axe explains the chances of getting a functional protein by chance

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I’ve talked about Doug Axe before when I described how to calculate the odds of getting functional proteins by chance.

Let’s calculate the odds of building a protein composed of a functional chain of 100 amino acids, by chance. (Think of a meaningful English sentence built with 100 scrabble letters, held together with glue)

Sub-problems:

  • BONDING: You need 99 peptide bonds between the 100 amino acids. The odds of getting a peptide bond is 50%. The probability of building a chain of one hundred amino acids in which all linkages involve peptide bonds is roughly (1/2)^99 or 1 chance in 10^30.
  • CHIRALITY: You need 100 left-handed amino acids. The odds of getting a left-handed amino acid is 50%. The probability of attaining at random only L–amino acids in a hypothetical peptide chain one hundred amino acids long is (1/2)^100 or again roughly 1 chance in 10^30.
  • SEQUENCE: You need to choose the correct amino acid for each of the 100 links. The odds of getting the right one are 1 in 20. Even if you allow for some variation, the odds of getting a functional sequence is (1/20)^100 or 1 in 10^65.

The final probability of getting a functional protein composed of 100 amino acids is 1 in 10^125. Even if you fill the universe with pre-biotic soup, and react amino acids at Planck time (very fast!) for 14 billion years, you are probably not going to get even 1 such protein. And you need at least 100 of them for minimal life functions, plus DNA and RNA.

Research performed by Doug Axe at Cambridge University, and published in the peer-reviewed Journal of Molecular Biology, has shown that the number of functional amino acid sequences is tiny:

Doug Axe’s research likewise studies genes that it turns out show great evidence of design. Axe studied the sensitivities of protein function to mutations. In these “mutational sensitivity” tests, Dr. Axe mutated certain amino acids in various proteins, or studied the differences between similar proteins, to see how mutations or changes affected their ability to function properly. He found that protein function was highly sensitive to mutation, and that proteins are not very tolerant to changes in their amino acid sequences. In other words, when you mutate, tweak, or change these proteins slightly, they stopped working. In one of his papers, he thus concludes that “functional folds require highly extraordinary sequences,” and that functional protein folds “may be as low as 1 in 10^77.”

The problem of forming DNA by sequencing nucleotides faces similar difficulties. And remember, mutation and selection cannot explain the origin of the first sequence, because mutation and selection require replication, which does not exist until that first living cell is already in place.

But you can’t show that to your friends, you need to send them a video. And I have a video!

A video of Doug Axe explaining the calculation

Here’s a clip from Illustra Media’s new ID DVD “Darwin’s Dilemma”, which features Doug Axe and Stephen Meyer (both with Ph.Ds from Cambridge University).

I hope you all read Brian Auten’s review of Darwin’s Dilemma! It was awesome.

Related DVDs

Illustra also made two other great DVDs on intelligent design. The first two DVDs “Unlocking the Mystery of Life” and “The Privileged Planet” are must-buys, but you can watch them on youtube if you want, for free.

Here are the 2 playlists:

I also recommend Coldwater Media’s “Icons of Evolution”. All three of these are on sale from Amazon.com.

Related posts

Commentary

Interview with Jim Spiegel on “The Making of an Atheist” book

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Interview here at the EPS blog.

Excerpt:

Why might there be a tendency among some Christian philosophical critiques of atheism (or any other worldview for that matter) to under-represent or downright avoid how the sinful tendencies of the human heart figure into the formation of a worldview?

One reason for avoidance of this issue might be a concern for decorum.  I suppose it could appear unseemly or offensive even to suggest, much less to present as a thesis of a book, that a person’s lack of belief in God is, at bottom, a form of rebellion.  And I must admit that at times I felt uncomfortable writing the book for this reason.  However, the fact that it is a clear biblical truth compelled me to write it anyway.  But I was careful to be as generous and winsome as I could manage, given the subject matter.

And:

How does one become “entrenched” in an atheist’s mindset?

In my book I expound on two aspects of this process, which explains something of the obstinacy of atheists.  There is a phenomenon that I call “paradigm-induced blindness,” where a person’s false worldview prevents them from seeing truths which would otherwise be obvious.  Additionally, a person’s sinful indulgences have a way of deadening their natural awareness of God or, as John Calvin calls it, the sensus divinitatis.  And the more this innate sense of the divine is squelched, the more resistant a person will be to evidence for God.

You say that right living contributes to the perseverance of faith. How is that perseverance related to Christian virtue and the “cognitive health” that it brings?

Just as sinful thoughts and behavior corrupt us cognitively and warp our perspective on the world, obedience and virtue benefit us cognitively in a number of ways.  Not only do we avoid the intellectual warping and deadening of the sensus divinitatis that sin causes, but Scripture also makes clear that God grants special insight and wisdom to those who obey him (cf. Ps. 19:7, Ps. 25:9; Pr. 1:4, Pr. 11:2).  So you might say that the life of Christian virtue enhances our ability to think and reason, especially about moral and spiritual matters.

I can hardly wait to read this book so that I can get some guidelines for dialoguing with atheists about how they formed their worldview. Is this really how atheists formed their view?

Polemics

Did Jesus really teach that it is wrong to judge others?

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Great post by Matt at MandM on an often misunderstood verse.

Here’s the passage in question, Matthew 7:1-5:

1“Do not judge, or you too will be judged.

2For in the same way you judge others, you will be judged, and with the measure you use, it will be measured to you.

3“Why do you look at the speck of sawdust in your brother’s eye and pay no attention to the plank in your own eye?

4How can you say to your brother, ‘Let me take the speck out of your eye,’ when all the time there is a plank in your own eye?

5You hypocrite, first take the plank out of your own eye, and then you will see clearly to remove the speck from your brother’s eye.

Most people only quote the first verse, but they don’t look at the rest of the verses that come after.

Here’s what Matt has to say about those other verses:

The phrase translated in the NIV as, “do not judge, or you too will be judged,” was originally written by Matthew in Koine (a Greek dialect). The Interlinear Bible gives the literal translation here as, “do not judge that you be judged.” In other words, do not judge others in a way that leads one to put oneself under judgement.

[…]One is not to judge in a way that brings judgment on oneself. The reason for this (“for”) is that the standard one uses to judge others is the standard that one’s own behaviour will be measured by. Jesus goes on to illustrate, with a sarcastic example, precisely what he is talking about; a person who nit-picks or censures the minor faults of others (taking the speck out of their brothers eye) who ignores the serious, grave, moral faults in their own life (the log in one’s own eye). His point is that such faults actually blind the person’s ability to be able to make competent moral judgments. This suggests that Jesus is focusing on a certain type of judging and not the making of judgments per se.

In fact, the conclusion that Jesus does not mean to condemn all judging of others is evident from the proceeding sentences in the above quote. Rather than engaging in the kind of judgment Jesus has condemned one should “first take the plank out of your own eye, and then you will see clearly to remove the speck from your brother’s eye.” In other words one should try to rectify the serious moral flaws in one’s own life precisely so one can assist others with theirs. One needs to avoid hypocrisy in order to make constructive and effective moral judgments about others. This would make no sense if Jesus meant to condemn all judging by this passage.

This is something I actually try to do, and it’s easy. Before you open your mouth to judge someone, you have to look at your own life and make sure that you don’t do the thing you’re condeming.

I try not to say anything about individual people at all, but just talk about behaviors in general that are harmful. I don’t ask people if they do any of those behaviors. If they try to tell me about their bad behaviors, I tell them that their personal lives are not up for discussion, unless they explicitly ask me to comment on their specific case. So, instead of saying “you’re bad!”, I say “this behavior is bad and here’s why”. And I make sure I don’t DO that behavior before I declare it as immoral!

I hear this challenge about Christians being too judgmental all the time from non-Christians. If you do, too, then you should definitely click through to MandM and read the whole thing. There’s a logical element, a common sense element and a hermeneutical element to this problem, and all are discussed by Matt. He’s a sharp guy, you’re bound to learn something new that you can use.

http://www.biblegateway.com/passage/?search=Matthew%207:1-6&version=NIV