How likely is it for blind forces to sequence a functional protein by chance?

How likely is it that you could swish together amino acids randomly and come up with a sequence that would fold up into a functional protein?

Evolution News reports on research performed by Doug Axe at Cambridge University, and published in the peer-reviewed Journal of Molecular Biology.

Excerpt:

Doug Axe’s research likewise studies genes that it turns out show great evidence of design. Axe studied the sensitivities of protein function to mutations. In these “mutational sensitivity” tests, Dr. Axe mutated certain amino acids in various proteins, or studied the differences between similar proteins, to see how mutations or changes affected their ability to function properly.10 He found that protein function was highly sensitive to mutation, and that proteins are not very tolerant to changes in their amino acid sequences. In other words, when you mutate, tweak, or change these proteins slightly, they stopped working. In one of his papers, he thus concludes that “functional folds require highly extraordinary sequences,” and that functional protein folds “may be as low as 1 in 10^77.”11 The extreme unlikelihood of finding functional proteins has important implications for intelligent design.

Just so you know, those footnotes say this:

[10.] Douglas D. Axe, “Estimating the Prevalence of Protein Sequences Adopting Functional Enzyme Folds,” Journal of Molecular Biology, 1-21 (2004); Douglas D. Axe, “Extreme Functional Sensitivity to Conservative Amino Acid Changes on Enzyme Exteriors,” Journal of Molecular Biology, Vol. 301:585-595 (2000).

[11.] Douglas D. Axe, “Estimating the Prevalence of Protein Sequences Adopting Functional Enzyme Folds,” Journal of Molecular Biology, 1-21 (2004).

And remember, you need a lot more than just 1 protein in order to create even the simplest living system. Can you generate that many proteins in the short time between when the Earth cools and the first living cells appear? Even if we spot the naturalist a prebiotic soup as big as the universe, and try to make sequences as fast as possible, it’s unlikely to generate even one protein in the time before first life appears.

Here’s Doug Axe to explain his research:

If you are building a protein for the FIRST TIME, you have to get it right all at once – not by building up to it gradually using supposed Darwinian mechanisms. That’s because there is no replication before you have the first replicator. The first replicator cannot rely on explanations that require replication to already be in place.

Bowdoin College bans Christian student groups on campus

From the radically leftist New York Times. (H/T Nancy P.)

Excerpt:

For 40 years, evangelicals at Bowdoin College have gathered periodically to study the Bible together, to pray and to worship. They are a tiny minority on the liberal arts college campus, but they have been a part of the school’s community, gathering in the chapel, the dining center, the dorms.

After this summer, the Bowdoin Christian Fellowship will no longer be recognized by the college. Already, the college has disabled the electronic key cards of the group’s longtime volunteer advisers.

In a collision between religious freedom and antidiscrimination policies, the student group, and its advisers, have refused to agree to the college’s demand that any student, regardless of his or her religious beliefs, should be able to run for election as a leader of any group, including the Christian association.

Similar conflicts are playing out on a handful of campuses around the country, driven by the universities’ desire to rid their campuses of bias, particularly against gay men and lesbians, but also, in the eyes of evangelicals, fueled by a discomfort in academia with conservative forms of Christianity. The universities have been emboldened to regulate religious groups by a Supreme Court ruling in 2010 that found it was constitutional for a public law school in California to deny recognition to a Christian student group that excluded gays.

At Cal State, the nation’s largest university system with nearly 450,000 students on 23 campuses, the chancellor is preparing this summer to withdraw official recognition from evangelical groups that are refusing to pledge not to discriminate on the basis of religion in the selection of their leaders. And at Vanderbilt, more than a dozen groups, most of them evangelical but one of them Catholic, have already lost their official standing over the same issue; one Christian group balked after a university official asked the students to cut the words “personal commitment to Jesus Christ” from their list of qualifications for leadership.

[…]The evangelical groups say they, too, welcome anyone to participate in their activities, including gay men and lesbians, as well as nonbelievers, seekers and adherents of other faiths. But they insist that, in choosing leaders, who often oversee Bible study and prayer services, it is only reasonable that they be allowed to require some basic Christian faith — in most cases, an explicit agreement that Jesus was divine and rose from the dead, and often an implicit expectation that unmarried student leaders, gay or straight, will abstain from sex.

“It would compromise our ability to be who we are as Christians if we can’t hold our leaders to some sort of doctrinal standard,” said Zackary Suhr, 23, who has just graduated from Bowdoin, where he was a leader of the Bowdoin Christian Fellowship.

The consequences for evangelical groups that refuse to agree to the nondiscrimination policies, and therefore lose their official standing, vary by campus. The students can still meet informally on campus, but in most cases their groups lose access to student activity fee money as well as first claim to low-cost or free university spaces for meetings and worship; they also lose access to standard on-campus recruiting tools, such as activities fairs and bulletin boards, and may lose the right to use the universities’ names.

Not sure how you are supposed to have a Christian student group, if the leaders don’t accept the authority of the Bible. But maybe that’s a feature, not a bug, from the point of view of these secular administrators and their allies in the judiciary. The really sad thing about this is that Christian taxpayers are paying these secular authorities to curtail their basic rights. It’s only open season on Bible-believing Christians.

Has Christianity held back the progress of science? What about Galileo?

First, here’s an article from the peer-reviewed journal Nature, probably the best peer-reviewed journal on science in the world.

The article is written by James Hannam. He has a PhD in the History and Philosophy of Science from the University of Cambridge and is the author of The Genesis of Science: How the Christian Middle Ages Launched the Scientific Revolution (published in the UK as God’s Philosophers: How the Medieval World Laid the Foundations of Modern Science).

Excerpt:

Few topics are as open to misunderstanding as the relationship between faith and reason. The ongoing clash of creationism with evolution obscures the fact that Christianity has actually had a far more positive role to play in the history of science than commonly believed. Indeed, many of the alleged examples of religion holding back scientific progress turn out to be bogus. For instance, the Church has never taught that the Earth is flat and, in the Middle Ages, no one thought so anyway. Popes haven’t tried to ban zero, human dissection or lightening rods, let alone excommunicate Halley’s Comet. No one, I am pleased to say, was ever burnt at the stake for scientific ideas. Yet, all these stories are still regularly trotted out as examples of clerical intransigence in the face of scientific progress.

Admittedly, Galileo was put on trial for claiming it is a fact that the Earth goes around the sun, rather than just a hypothesis as the Catholic Church demanded. Still, historians have found that even his trial was as much a case of papal egotism as scientific conservatism. It hardly deserves to overshadow all the support that the Church has given to scientific investigation over the centuries.

That support took several forms. One was simply financial. Until the French Revolution, the Catholic Church was the leading sponsor of scientific research. Starting in the Middle Ages, it paid for priests, monks and friars to study at the universities. The church even insisted that science and mathematics should be a compulsory part of the syllabus. And after some debate, it accepted that Greek and Arabic natural philosophy were essential tools for defending the faith. By the seventeenth century, the Jesuit order had become the leading scientific organisation in Europe, publishing thousands of papers and spreading new discoveries around the world. The cathedrals themselves were designed to double up as astronomical observatories to allow ever more accurate determination of the calendar. And of course, modern genetics was founded by a future abbot growing peas in the monastic garden.

But religious support for science took deeper forms as well. It was only during the nineteenth century that science began to have any practical applications. Technology had ploughed its own furrow up until the 1830s when the German chemical industry started to employ their first PhDs. Before then, the only reason to study science was curiosity or religious piety. Christians believed that God created the universe and ordained the laws of nature. To study the natural world was to admire the work of God. This could be a religious duty and inspire science when there were few other reasons to bother with it. It was faith that led Copernicus to reject the ugly Ptolemaic universe; that drove Johannes Kepler to discover the constitution of the solar system; and that convinced James Clerk Maxwell he could reduce electromagnetism to a set of equations so elegant they take the breathe away.

Given that the Church has not been an enemy to science, it is less surprising to find that the era which was most dominated by Christian faith, the Middle Ages, was a time of innovation and progress. Inventions like the mechanical clock, glasses, printing and accountancy all burst onto the scene in the late medieval period. In the field of physics, scholars have now found medieval theories about accelerated motion, the rotation of the earth and inertia embedded in the works of Copernicus and Galileo. Even the so-called “dark ages” from 500AD to 1000AD were actually a time of advance after the trough that followed the fall of Rome. Agricultural productivity soared with the use of heavy ploughs, horse collars, crop rotation and watermills, leading to a rapid increase in population.

I hope this will set the record straight – Judeo-Christian monotheism created the enterprise of experimental science.

Positive arguments for Christian theism