Tag Archives: Treatment

EEG device detects consciousness in persons in persistent vegetative state

Here’s an interesting article from the New Scientist.

Excerpt:

Signs of consciousness have been detected in three people previously thought to be in a vegetative state, with the help of a cheap, portable device that can be used at the bedside.

“There’s a man here who technically meets all the internationally agreed criteria for being in a vegetative state, yet he can generate 200 responses [to direct commands] with his brain,” says Adrian Owen of the University of Western Ontario. “Clearly this guy is not in a true vegetative state. He’s probably as conscious as you or I are.”

[Owen’s team] devised a test that uses the relatively inexpensive and widely available electroencephalogram (EEG).

An EEG uses electrodes attached to the scalp to record electrical activity in the brain.

Owen and his team used an EEG on 16 people thought to be in a PVS and compared the results with 12 healthy controls while they were asked to imagine performing a series of tasks.

Each person was asked to imagine at least four separate actions – either clenching their right fist or wiggling their toes.

In three of the people with PVS, brain regions known to be associated with those tasks lit up with activity, despite physical unresponsiveness. This suggested to the researchers that the subjects were carrying out a complex set of cognitive functions including hearing the command, understanding language, sustaining attention and tapping into working memory.

“It isn’t the case that just because somebody doesn’t respond they’re not conscious,” Owen says. “There’s a growing body of data now demonstrating that many of these patients aren’t what they appear.”

The rest of the article talks about how the scientists are planning to use their new technique to communicate with patients by asking them to think of specific things which will mean “yes” or “no”. The long-term goal is to get the patients to be able to communicate, perhaps even allow them to move a mouse pointer by triggering reactions in their brains by using their thoughts.

I think this research dovetails nicely with the OCD research I mentioned before. Maybe now would be a good time to talk more about that research.

William Dembski discusses the OCD research of Jeffrey Schwartz.

Excerpt:

Schwartz provides a nonmaterialist interpretation of neuroscience and argues that this interpretation is more compelling than the standard materialist interpretation. He arrived at this position as a psychiatrist specializing in the treatment of obsessive-compulsive disorder (OCD). OCD sufferers recognize obsessive-compulsive thoughts and urges as separate from their intrinsic selves. For instance, after a few washings, the compulsive hand-washer realizes that his hands are clean and yet feels driven to keep washing them. It was reflection on this difference between the obvious truth (the hands are clean) and the irrational doubts (they might still be dirty) that prompted Schwartz to reassess the philosophical underpinnings of neuroscience.

From brain scans, Schwartz found that certain regions in the brain of OCD patients (the caudate nucleus in particular) exhibited abnormal patterns of activity. By itself this finding is consistent with a materialist view of mind (if, as materialism requires, the brain enables the mind, then abnormal patterns of brain activity are likely to be correlated with dysfunctional mental states). Nonetheless, having found abnormal patterns of brain activity, Schwartz then had OCD patients engage in intensive mental effort through what he called relabeling, reattributing, refocusing, and revaluing (the 4 Rs). In the case of compulsive hand-washing, this involved a patient acknowledging that his hands were in fact clean (relabeling); attributing anxieties and doubts about his hands being dirty to a misfunctioning brain (reattributing); directing his thoughts and actions away from handwashing and toward productive ends (refocusing); and, lastly, understanding at a deep level the senselessness of OCD messages (revaluing).

Schwartz documents not only that patients who undertook this therapy experienced considerable relief from OCD symptoms, but also that their brain scans indicated a lasting realignment of brain-activity patterns. Thus, without any intervention directly affecting their brains, OCD patients were able to reorganize their brains by intentionally modifying their thoughts and behaviors. The important point for Schwartz here is not simply that modified thoughts and behaviors permanently altered patterns of brain activity, but that such modifications resulted from, as he calls it, “mindful attention”-conscious and purposive thoughts or actions in which the agent adopts the stance of a detached observer.

It turns out that people can freely choose to exert “mental effort” in order to change what their brains are doing.

By the way, if you like this topic, and want a resource to show your friends, be sure and get a hold of the debate on mind vs. brain between Jeffrey M. Schwartz and Michael Shermer.

Induced abortions, drinking and use of contraceptives all increase breast cancer risk

Here’s the latest study from the Journal of the American Medical Association (JAMA), showing that excessive consumption of alcohol is a rish factor for breast cancer.

Excerpt:

Consumption of 3 to 6 alcoholic drinks per week is associated with a small increase in the risk of breast cancer, and consumption in both earlier and later adult life is also associated with an increased risk, according to a study in the November 2 issue of JAMA.

“In many studies, higher consumption of alcohol has been associated with an increased risk of breast cancer. However, the effect of low levels of drinking as is common in the United States has not been well quantified,” according to background information in the article. “In addition, the role of drinking patterns (i.e., frequency of drinking and ‘binge’ drinking) and consumption at different times of adult life are not well understood.”

Wendy Y. Chen, M.D., M.P.H., of Brigham and Women’s Hospital and Harvard Medical School, Boston, and colleagues examined the association of breast cancer with alcohol consumption during adult life, including quantity, frequency, and age at consumption. The study included 105,986 women enrolled in the Nurses’ Health Study who were followed up from 1980 until 2008 with an early adult alcohol assessment and 8 updated alcohol assessments. The primary outcome the researchers measured was the risk of developing invasive breast cancer.

During the follow-up period, there were 7,690 cases of invasive breast cancer diagnosed among the study participants. Analyses of data indicated that a low level of alcohol consumption (5.0 to 9.9 grams per day, equivalent to 3-6 glasses of wine per week) was modestly but statistically significantly associated with a 15 percent increased risk of breast cancer. In addition, women who consumed at least 30 grams of alcohol daily on average (at least 2 drinks per day) had a 51 percent increased risk of breast cancer compared with women who never consumed alcohol.

The researchers also found that when examined separately, alcohol consumption levels at ages 18 to 40 years and after age 40 years were both strongly associated with breast cancer risk. The association with drinking in early adult life still persisted even after controlling for alcohol intake after age 40 years.

Binge drinking, but not frequency of drinking, was also associated with breast cancer risk after controlling for cumulative alcohol intake.

Now let’s take a look at some other factors that raise the risk of breast cancer.

Abortion and breast cancer

Many studies show a link between abortion and breast cancer.

Study 1: (September 2010)

Based on the expression of estrogen receptor (ER), progesterone receptor (PR) and HER2/neu (HER2), breast cancer is classified into several subtypes: luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+, HER2+), HER2-overexpressing (ER-, PR-, and HER2+) and triple-negative (ER-, PR-, and HER2-). The aim of this case-control study is to determine reproductive factors associated with breast cancer subtypes in Chinese women. A total of 1,417 patients diagnosed with breast cancer in the First Affiliated Hospital, China Medical University, Shenyang, China between 2001 and 2009 and 1,587 matched controls without a prior breast cancer were enrolled.

[…]Postmenopause and spontaneous abortion were inversely associated with the risk of luminal tumors. By contrast, multiparity, family history of breast cancer and induced abortion increased the risk of breast cancer.

Study 2: (March 2010)

OBJECTIVE: To explore the risk factors of breast cancer for better control and prevention of the malignancy.

METHODS: The clinical data of 232 patients with pathologically established breast cancer were investigated in this 1:1 case-control study to identify the risk factors of breast cancer.

RESULTS: The history of benign breast diseases, family history of carcinoma and multiple abortions were the statistically significant risk factors of breast cancer, while breast feeding was the protective factor.

CONCLUSION: A history of benign breast diseases, family history of carcinoma and multiple abortions are all risk factors of breast cancer.

But wait, there’s more.

Birth control pills

Many studies showed that taking birth control pills caused an increased risk of breast cancer.

Study 1: (March 2003)

RESULTS: Among the youngest age group (<35 years, n = 545), significant predictors of risk included African-American race (RR = 2.66: 95% CI 1.4-4.9) and recent use of oral contraceptives (RR = 2.26; 95% CI 1.4-3.6). Although these relationships were strongest for estrogen receptor-negative (ER-) tumors (RRs of 3.30 for race and 3.56 for recent oral contraceptive use), these associations were also apparent for young women with ER+ tumors. Delayed childbearing was a risk factor for ER+ tumors among the older premenopausal women (Ptrend < 0.01), but not for women <35 years in whom early childbearing was associated with an increased risk, reflecting a short-term increase in risk immediately following a birth.

Study 2: (October 2008)

Oral contraceptive use ≥1 year was associated with a 2.5-fold increased risk for triple-negative breast cancer (95% confidence interval, 1.4-4.3) and no significantly increased risk for non-triple-negative breast cancer (Pheterogeneity = 0.008). Furthermore, the risk among oral contraceptive users conferred by longer oral contraceptive duration and by more recent use was significantly greater for triple-negative breast cancer than non-triple-negative breast cancer (Pheterogeneity = 0.02 and 0.01, respectively).

Why are these risk factors so prevalent today?

Now let’s put it all together by looking at this New York Times article by Nancy Bauer.

Excerpt:

If there’s anything that feminism has bequeathed to young women of means, it’s that power is their birthright.  Visit an American college campus on a Monday morning and you’ll find any number of amazingly ambitious and talented young women wielding their brain power, determined not to let anything — including a relationship with some needy, dependent man — get in their way.  Come back on a party night, and you’ll find many of these same girls (they stopped calling themselves “women” years ago) wielding their sexual power, dressed as provocatively as they dare, matching the guys drink for drink — and then hook-up for hook-up.

The article was written by:

Nancy Bauer is associate professor and chair of philosophy at Tufts University. She is the author of “Simone de Beauvoir, Philosophy, and Feminism,” and is currently completing a new book, “How to Do Things With Pornography.”

Her comments cause me to ask some questions. Where did women ever get the idea that they had to drink as much as men drink? Where did women ever get the idea that using contraceptives to enable hook-up sex was healthy and normal? Where did women ever get the idea that aborting their own unborn children was healthy and normal? Is there one unifying worldview that stipulates all of these beliefs? Why has this worldview become so popular that so many young women who now believe in it, rather than believing in traditional Judeo-Christian values?

Who is paying for all of this increased health care spending?

The total cost for breast cancer treatment, which raises medical insurance premiums (private health care) or taxes (single-payer health care), has been estimated to be between $1.8 billion and $3.8 billion dollars. In addition, the government spends billions of dollars each year on breast cancer research. All of this spending is costing taxpayers a lot of money, as people demand more and more government funding of breast cancer research and breast cancer treatment (with either private or single-payer health care).

New study: adult stem cells are almost identical to embryonic stem cells

From Life News.

Excerpt:

Scientists at the University of Wisconsin-Madison have used detailed, high-tech analysis to examine the differences between human embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC).

Their findings, published online in the journal Nature Methods, for the first time measured the differences between ESC and iPSC in terms of their proteins (the workhorses of the cell that provide structure, function, and identity for a cell), phosphorylation of proteins (a common type of protein modification used to control protein activity), and RNA (an intermediate messenger from DNA that codes for specific proteins.)  The results indicate that there is significant similarity between ESC and iPSC, with less than 1 percent difference.

ESC research relies on the destruction of a young human embryo, while iPS cells are produced by adding a few genes to normal cells, such as skin, thereby reprogramming the cell to look and act like an ESC, yet without the use of embryos, eggs, or cloning techniques.  The iPS cells thus have a couple of advantages over ESC, including their ethical production as well as the ability to produce pluripotent stem cells directly from any person, to study disease or for potential transplant matching (though the latter has not been proven.)  The similarities indicate, however, that iPSC are more than adequate alternatives to ESC.

The study points out that some differences do still exist between ESC and iPSC, likely as a result of the different origins of the two stem cell types, and that further studies will examine those differences.  But the authors state in their paper that “These differences do not appear to appreciably alter cellular function in the pluripotent state,” as in not affecting the growth and function of iPSC as a stem cell, and the “remarkable similarity between ESCs and iPSCs.”

It’s time to stop the destruction of embryos for experiments, and focus on ethical science.

See below for some adult stem cell successes.

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