Tag Archives: Sequence

News

MUST-READ: Doug Axe defends intelligent design at science conference in Germany

4 Comments

Doug Axe got his Ph.D from Caltech and did post-doc research at Cambridge University, and published some of his findings in the peer-reviewed Journal of Molecular Biology. He was trying to see whether it is easy or hard to shuffle amino acids randomly in order to make functional proteins. Those JMB publications show that the number of functional amino acid sequences is tiny, compared to the number of possible sequences.

Doug Axe’s research likewise studies genes that it turns out show great evidence of design. Axe studied the sensitivities of protein function to mutations. In these “mutational sensitivity” tests, Dr. Axe mutated certain amino acids in various proteins, or studied the differences between similar proteins, to see how mutations or changes affected their ability to function properly. He found that protein function was highly sensitive to mutation, and that proteins are not very tolerant to changes in their amino acid sequences. In other words, when you mutate, tweak, or change these proteins slightly, they stopped working. In one of his papers, he thus concludes that “functional folds require highly extraordinary sequences,” and that functional protein folds “may be as low as 1 in 10^77.”

And now let’s see what he was up to in Stuttgart, Germany.

Story here from Evolution News.

Excerpt:

While there have been many events to discuss intelligent design sponsored by the scientific establishment this year, few have dared to invite an actual design proponent.

But on the 150th anniversary of On the Origin of Species, Biologic Institute Director Douglas Axe was invited to the National Museum of Natural History in Stuttgart, Germany, for a panel discussion titled Design without a Designer? where “the ‘bold generation’ of young thinkers turned up in droves, listening intently as the discussion went well beyond its advertised ninety minutes.”

Here’s the official description of the event (in German), and a translated excerpt:

On the occasion of the 150th anniversary of the first publication of Darwin’s theory, this high-caliber panel discussion between evolutionists and Darwin critics will consider the question of whether the evolution of life on Earth is based solely on blind and unguided natural processes, or whether there is non-religiously based, verifiable evidence of meaningful and purposeful acts of creative intelligence in the natural world. This meeting at the Stuttgart Museum of Natural History aims to contribute constructively and with clarity and objectivity to this important debate. A public debate between evolutionary biologists and evolutionary critics at this high level is very rare in Germany, and therefore can be expected to be a very exciting evening.

You can read more at the Biologic Institute. They even have excerpts from Doug’s opening statement. It’s short and to the point.

Excerpt:

William Dembski and Stephen Meyer have both framed the design argument in terms of functional information, meaning information that specifies a significant functional outcome.  Since this fits well with my own understanding, I offer the following three-statement summary of the design argument:

First: Living things contain within their genomes large amounts of functional information.

Second: The only cause known to be capable of generating large amounts of functional information is intelligence.

And third: It is therefore reasonable to infer that the functional information in living things must have an intelligent source.

Here we have not a pronouncement but an argument based on evidence and logic.  It is perfectly fair to argue against it, of course, but it is hardly fair to dismiss it as dogma.

I like this, because I am a software engineer. This is what we do.

Polemics

How long will it take to sort a deck of cards by trial and error?

1 Comment

Inside the cell, things like proteins and DNA are formed by sequencing parts together in just the right way so that the sequence will have biological function. If the sequence is wrong, because some component of the sequence is the wrong piece or is in the wrong place, the sequence has no function. It’s just like writing English or computer instructions.

To calculate the probabilities, you have to use a rule called “The Product Rule”, because the order of the parts in the sequence (“permutation”) is important. For example, the odds of getting the sequence “ABC” just by choosing three random letters is 1/26 x 1/26 x 1/26 = 1/17576. Things get very unlikely quite quickly, don’t they?

So, take a look at Neil Simpson’s latest post, where he uses cards instead of letters or amino acids, but the principle is exactly the same. His calculation is a little different because the odds actually go down a little each time you choose a card. So, for the first card, it’s 1/52, but the second card is only 1/51, and so on…

Excerpt:

This is by no means a definitive argument against evolution, but I offer it to put the “time, chance and random mutation” theory in perspective.

Everyone knows that micro-evolution occurs, such as dog breeding and bacteria becoming resistant to antibiotics.  But macro-evolutionists believe that with enough time an amazingly complex single cell of unknown origin could make lots and lots of small changes, develop reproductive capacities and eventually become humans, elephants, caterpillar/butterflies, chameleons and so much more.

Let’s consider something very simple.  Imagine that you shuffle a deck of cards.  If you shuffled it one time per second, how often would all the cards go back into their original order? (Ace of spades, King of spades, etc.)  The math is simply 1/52 (the odds of the Ace of spades being on top) times 1/51 times 1/50, etc. I left out the Jokers to make it easier.

Guess how many years it takes?

Click through to see his calculations, or do them yourself! It’s easy and fun! Neil has a pretty fun discussion going on with the angry atheists who frequent his site, too.

This is everyone should learn probabilities in school, because then we can really talk about these things with our neighbor. Shalini can even do biochemistry, so she can actually explain it even better than I can!

Remember, we are looking for a specific sequence of cards – the sequence that the cards originally came in. In this example, it’s that sequence and that sequence alone that has biological function. The other sequences are just junk – they have no biological function. And most importantly, you don’t get to save any of the cards that are in the right spots because the sequence as a whole has no present function that would allow it to be “saved” for later. You have to re-select all 52 cards each time at random!

A typical protein isn’t made of 52 parts, it’s made of around 200, and there are 80 possible amino acids, not just 26! And in the case of proteins,the vast majority of the possible sequences that you can make won’t have any biological function at all! (And there are many more problems besides, such as chirality, cross reactions, and bonding type). Even if you filled the whole universe with reactants and reacted it all at Planck time, for the entire history of the universe, you still wouldn’t be likely to get even one protein!

You can read more about the origin of life in this post.

Commentary

Is the presupposition of naturalism a science stopper?

7 Comments

UPDATE: Welcome readers from 4Simpsons! Thanks for the link Neil!

In cosmology, we had to wait decades for the theism-friendly big bang theory to beat out atheism-friendly theories like the eternal universe model, the steady-state model, the oscillating model, etc. Piles of taxpayer money wasted trying to prove atheistic flights of fancy. But in the end, the evidence for the big bang was too much for the atheistic theories, and we beat them out.

Junk DNA

And here is another example of how atheism is bad for scientific inquiry: “Junk DNA”.

The purpose of the genome is to contain the instructions that allow the cell to build functional sequences of smaller components. If the sequences are done right, you get a folded-up protein that can be used for all kinds of things.

But what those parts of the genome that don’t code for proteins? Well, atheists have been calling them “Junk DNA” and hailing it as proof that there is no designer to life. I can remember Christian groups like Reasons to Believe predicting that a purpose for “Junk DNA” would be found. But atheists pooh-pooh’d that idea. Gee, I wonder who was right? The same people who are always right: THEISTS.

Denyse O’Leary cites this Princeton University press release on Post-Darwinist:

Now researchers from Princeton University and Indiana University who have been studying the genome of a pond organism have found that junk DNA may not be so junky after all. They have discovered that DNA sequences from regions of what had been viewed as the “dispensable genome” are actually performing functions that are central for the organism. They have concluded that the genes spur an almost acrobatic rearrangement of the entire genome that is necessary for the organism to grow.

…The term “junk DNA” was originally coined to refer to a region of DNA that contained no genetic information. Scientists are beginning to find, however, that much of this so-called junk plays important roles in the regulation of gene activity. No one yet knows how extensive that role may be.

She’s got a stack of other related links at the bottom of the post.

Commenter ECM also sent me this story from Cornelius Hunter’s new blog.

Excerpt:

One problem with evolution is its strong bias toward viewing everything in biology as a kludge. When a newly discovered structure is examined, evolutionists take one look and conclude it is leftover junk. After all, blind, unguided mutations and other processes just happened to produce everything we see. The evolutionist’s going in position is that biology is a fluke. We’re lucky anything works.

Hunter then cites this passage from some naturalist researchers who study “junk DNA”:

Here we have a molecule that serves an important role in how cells function and survive, but it contains these puzzling ‘junk’ sequences that don’t seem to have any apparent purpose. Our work suggests that this disorder is really a way of creating flexibility, allowing the protein to function as a molecular switch, a process that is thought to go wrong in certain diseases.

Evolution has provided researchers with convenient modular structures, areas that are repeated over and over again to make up proteins, and so we tend to dismiss the interspersed disordered sequences that don’t seem to have any definable structure. Here we show that the weak molecular interactions in a disorganized protein sequence are essential in giving this protein its unique attributes.

Know what? If you substitute “Flying Spaghetti Monster” in there for “Evolution”, it makes just as much sense! Try it! Evolution causes toothpaste to come out of the toothpaste tube when you squeeze it, and Shakespearean rhyming couplets to rhyme, and my Java code to compile. It’s all evolution!

Conclusion

Atheists, always remember this quote from agnostic NASA astronomer Robert Jastrow, regarding the progress of science:

For the scientist who has lived by his faith in the power of reason, the story ends like a bad dream. He has scaled the mountains of ignorance; he is about to conquer the highest peak; as he pulls himself over the final rock, he is greeted by a band of theologians who have been sitting there for centuries.

In the 1920s, there was no theory about a universe that begins to exist out of nothing, no fine-tuning, no DNA, no Cambrian explosion, nothing. Then science progressed, reducing atheism to a kind of childish delusion, still believed by ignorant snake-handlers and people with certain persistent moral, … ah… issues. But that’s what psychiatrists are for!

Science is always for us, it’s never for you. You have faith. Blind faith. We have all the evidence. We invented science, and every new discovery makes your materialism look more silly and naive… you bravely hold out hope for some hopeful Flying Spaghetti Monster to swoop in and rescue your atheism from the big, bad mind-independent reality. When will you grow up?

There is no Flying Spaghetti Monster!