Yale University computer science professor takes a look at protein formation probabilities

How did life begin?
How did life begin?

When I was in graduate school, we studied a book called “Mirror Worlds”, authored by famous computer science professor David Gelernter at Yale University. This week, I noticed that Dr. Gelernter had written an article in the prestigious Claremont Review of Books. In his article, he applies his knowledge of computer science to the problem of the origin of life.

Evolution, if it is going to work at all, has to explain the problem of how the basic building blocks of life – proteins – can emerge from non-living matter. It turns out that the problem of the origin of life is essentially a problem of information – of code. If the components of proteins are ordered properly, then the sequence folds up into a protein that has biological function. If the sequence is not good, then just like computer code, it won’t run.

Here’s Dr. Gelernter to explain:

How to make proteins is our first question. Proteins are chains: linear sequences of atom-groups, each bonded to the next. A protein molecule is based on a chain of amino acids; 150 elements is a “modest-sized” chain; the average is 250. Each link is chosen, ordinarily, from one of 20 amino acids. A chain of amino acids is a polypeptide—“peptide” being the type of chemical bond that joins one amino acid to the next. But this chain is only the starting point: chemical forces among the links make parts of the chain twist themselves into helices; others straighten out, and then, sometimes, jackknife repeatedly, like a carpenter’s rule, into flat sheets. Then the whole assemblage folds itself up like a complex sheet of origami paper. And the actual 3-D shape of the resulting molecule is (as I have said) important.

Imagine a 150-element protein as a chain of 150 beads, each bead chosen from 20 varieties. But: only certain chains will work. Only certain bead combinations will form themselves into stable, useful, well-shaped proteins.

So how hard is it to build a useful, well-shaped protein? Can you throw a bunch of amino acids together and assume that you will get something good? Or must you choose each element of the chain with painstaking care? It happens to be very hard to choose the right beads.

Gelernter decides to spot the Darwinist a random sequence of 150 elements. Now the task the Darwinist is to use random mutation to arrive at a sequence of 150 links that has biological function.

[W]hat are the chances that a random 150-link sequence will create such a protein? Nonsense sequences are essentially random. Mutations are random. Make random changes to a random sequence and you get another random sequence. So, close your eyes, make 150 random choices from your 20 bead boxes and string up your beads in the order in which you chose them. What are the odds that you will come up with a useful new protein?

[…]The total count of possible 150-link chains, where each link is chosen separately from 20 amino acids, is 20150. In other words, many. 20150 roughly equals 10195, and there are only 1080 atoms in the universe.

What proportion of these many polypeptides are useful proteins? Douglas Axe did a series of experiments to estimate how many 150-long chains are capable of stable folds—of reaching the final step in the protein-creation process (the folding) and of holding their shapes long enough to be useful. (Axe is a distinguished biologist with five-star breeding: he was a graduate student at Caltech, then joined the Centre for Protein Engineering at Cambridge. The biologists whose work Meyer discusses are mainly first-rate Establishment scientists.) He estimated that, of all 150-link amino acid sequences, 1 in 1074 will be capable of folding into a stable protein. To say that your chances are 1 in 1074 is no different, in practice, from saying that they are zero. It’s not surprising that your chances of hitting a stable protein that performs some useful function, and might therefore play a part in evolution, are even smaller. Axe puts them at 1 in 1077.

In other words: immense is so big, and tiny is so small, that neo-Darwinian evolution is—so far—a dead loss. Try to mutate your way from 150 links of gibberish to a working, useful protein and you are guaranteed to fail. Try it with ten mutations, a thousand, a million—you fail. The odds bury you. It can’t be done.

Keep in mind that you need many, many proteins in order to have even a simple living cell. (And that’s not even considering the problem of organizing the proteins into a system).

So, if you’re a naturalist, then your only resources to explain the origin of life are chance and mutation. As Dr. Gelernter shows, naturalistic explanations won’t work to solve even part of the problem. Not even with a long period of time.  Not even if you use the entire universe as one big primordial soup, and keep trying sequences for the history of the universe. It just isn’t possible to arrive at sequences that have biological function in the time available, using the resources available. The only viable explanation is that there is a computer scientist who wrote the code without using trial and error. Something that ordinary software engineers like myself and Dr. Gelernter do all the time. We know what kind of cause is adequate to explain functioning code.

Whose job is it to teach young, unmarried women not to delay marriage?

A group of feminists protesting people they disagree with
A group of feminists protesting people they disagree with

I found a very interesting post on a blog called Oz Conservative, which is run by an Australian traditional conservative. In the post, he looks at two women who wasted their 20s on fun and thrills. Both of them are childless and unmarried. And they are complaining that they should be married with children. How did it happen?

Excerpt:

Rachael spent her youth going out with the bad boy type:

relationships have never been my strong point. Historically, I’ve picked good-looking villains and addictive personalities.

I’ve had a ball and many passionate experiences, but nothing functional enough to constitute a long-term future and never anyone ‘normal’ enough to bring home to meet the parents.

Although she puts a positive spin on being single, she admits:

I’m realistic. I’ve probably missed the boat as far as children are concerned, and that is a shame…

[…]Yes, the life I have today is not quite the one I envisaged 20 years ago as a young woman. I foresaw a satisfying career along with 2.4 children and a handsome husband.

Then there is Bibi, now 44. She tells her story this way:

I am staring down the barrel of a lonely future without a man, let alone children.

And how do I find myself in this perilous position? One reason is undoubtedly that men like young women. Yes, I was young once and all that. In my 20s and 30s I wasn’t exactly a supermodel, but I was constantly surrounded by men. The trouble is I wasn’t necessarily looking to settle down back then…

Now that I am, there are very few available men out there and the ones there are would be more interested in my teenage nieces than in me…

[…]Bibi has a lot of friends in exactly the same boat:

In my close circle of friends, there are eight of us who are single and childless. This is a generational phenomenon  –  we are all aged between 37 and 45.

When our mothers were that age, such numbers would be unimaginable.

Like many women writing this kind of literature, when she looks back she recognises the negative influence of feminism on her generation of women:

I think the feminist teachings of the Sixties and Seventies seeped into our brains. My mum couldn’t be called a feminist, but I, too, grew up thinking we could be anything we wanted to be and have a fulfilling career, life and relationship…

[…]What she is trying to say here is that feminism pushed marriage and motherhood down the list of priorities (“there was more to contend with beforehand”). She admits that she was led into the magical kind of thinking I described earlier in which there is nothing in reality to limit having things as you want them to be (“we didn’t realise that men wouldn’t be interested … my generation was spoilt – unrealistic, even”).

The comments to the post are very interesting.

I was thinking about whose job it was to warn young Christian women about these bad choices, and I remembered a passage from the Bible.

Titus 2:3-5 explains:

3 Likewise, teach the older women to be reverent in the way they live, not to be slanderers or addicted to much wine, but to teach what is good.

4 Then they can urge the younger women to love their husbands and children,

5 to be self-controlled and pure, to be busy at home, to be kind, and to be subject to their husbands, so that no one will malign the word of God.

The problem is that many older Christian women made a lot of mistakes in their youth, especially with alcohol and premarital sex. And for most of them, it’s more important that they not feel guilty about it, than that they warn younger women not to make the same mistakes. So, instead of admitting guilt and setting boundaries, they often tell young women that it doesn’t matter what you do in your 20s because God, the cosmic butler, will make everything work out in the end.

We just had a situation where one woman who had a successful marriage tried to give younger women some very basic advice about how to be attractive to marriage-minded men. And what happened was that she was attacked by pretty much everyone. The reaction seemed to be strongest from Christian women, however, who insisted that God’s grace meant that Christian women didn’t have to care what the Bible taught about morality and wisdom. The important thing was that they follow their desires in the moment, because to exercise self-control would be “horrible” and would “send the wrong message”. Telling a woman not to do what she feels like is worse than murder, because women must always do what feels good. Who cares about the words of the Bible, when a woman has feelings that are a direct line to God’s mysterious will for her happiness?

One of the commenters on this blog put it this way:

I’ve been observing this phenomenon among so-called “Christians” for well over a decade. Concepts like “tolerance” and not being “judgmental” took hold in our culture and many Christians absorbed the mindset completely. If you point out that what someone is doing is sinful or might potentially lead to sinful behavior, they act defensive or turn the tables on you and say “well, you’re not perfect either!” Some even say that they do certain things for the express purpose of not being “legalistic,” because clearly, legalism is far worse than compromising one’s witness. Jesus has become a postmodern hippie whose primary message is “let’s all be cool to each other.” The only sins left are transgressions against the belief that everyone is equal and worthy of acceptance.

In reading the responses to Lori Alexander’s article, my greatest takeaway is that people are rationalization machines. If they’ve made mistakes, they won’t humbly acknowledge them and use the wisdom of their experience to guide others in the right direction. Instead, they’ll try to find a way to argue that their mistakes weren’t mistakes at all, and that the real sinner is the person who’s judging them for what they did. It’s a deceitful, selfish game, and anyone who plays it is an enemy of the Gospel. Their argument essentially boils down to “every woman, regardless of whatever bad decisions she’s made in life, is entitled to a loving husband who’ll provide for her.” Same way everyone’s entitled to free health care, regardless of whether sufficient medical resources exist, I suppose. It doesn’t work that way, ladies.

And they use this feminist scare word “shaming.” How dare you “shame” me? I would go so far as to say that shaming is a good thing, because it incentivizes proper behavior. Men have good reasons for wanting their wives to be virgins, and if you remove the stigma against premarital sex, a lot of women are going to take Biblical teaching on the subject less seriously. If Christian men as a whole agreed that they would only marry virgins, I guarantee you that a lot of women would think twice about what kind of men they associated with. If you feel “shamed,” it’s probably a sign that you haven’t truly repented of your sins. Sin separates us from God, and if you see your sins for what they are, you should have no problem condemning the sins that you yourself have committed and discouraging them in others.

I’m sorry for this long-winded ramble, but it disgusts me how much politically correct rot has infested the churches, and this entire incident just confirms that Paul was correct to forbid women teaching. When everyone is afraid of upsetting women, we get false teachers popping up everywhere spreading a destructive message with nothing but rhetoric behind it. The end result? Fewer marriages, fewer children, fewer people taking Christian teachings seriously, and more people being miserable and lonely. Once you start ceding ground to liberalism, the whole thing eventually unravels. Lots of good Christian men and women can’t find a spouse anymore, because their society has lied to them and they don’t realize it until it’s too late. Did their churches stand against the world? Did their churches provide them the guidance they needed? Or were their churches too afraid to be seen as “out of touch,” and did they prioritize numbers over holiness and correct teaching? If we are sincere believers, it should be obvious which is more important.

Many of the women who chose to delay marriage for fun and thrills with the bad boys grew up in married Christian homes. Parents and pastors have, for one reason or another, decided that it is too unpleasant to warn young Christian women that their behavior may involve some costs in the long term. They don’t want to make them feel bad, and women’s feelings are so very much more important than what the Bible says, or even what peer-reviewed research on marriage best practices says. Even theologically conservative pastors just don’t have the courage to address the influence that feminism has had on the goal-setting and decision-making of young, unmarried women. It’s much easier to blame men when the woman’s fun and thrills plan doesn’t work out.

How the WMAP satellite confirmed nucleosynthesis predictions and falsified atheism

Christianity and the progress of science
Christianity and the progress of science

Prior to certain scientific discoveries, most people thought that the universe had always been here, and no need to ask who or what may have caused it. But today, that’s all changed. Today, the standard model of the origin of the universe is that all the matter and energy in the universe came into being in an event scientists call “The Big Bang”. At the creation event, space and time themselves began to exist, and there is no material reality that preceded them.

So a couple of quotes to show that.

An initial cosmological singularity… forms a past temporal extremity to the universe. We cannot continue physical reasoning, or even the concept of spacetime, through such an extremity… On this view the big bang represents the creation event; the creation not only of all the matter and energy in the universe, but also of spacetime itself.

Source: P. C. W. Davies, “Spacetime Singularities in Cosmology,” in The Study of Time III, ed. J. T. Fraser (Berlin: Springer Verlag ).

And another quote:

[A]lmost everyone now believes that the universe, and time itself, had a beginning at the big bang.

Source: Stephen Hawking and Roger Penrose, The Nature of Space and Time, The Isaac Newton Institute Series of Lectures (Princeton, N. J.: Princeton University Press, 1996), p. 20.

So, there are several scientific discoveries that led scientists to accept the creation event, and one of the most interesting and famous is the discovery of how elements heavier than hydrogen were formed.

Nucleosynthesis: forming heavier elements by fusion
Nucleosynthesis: forming heavier elements by fusion

Here’s the history of how that discovery happened, from the National Aeronautics and Space Administration (NASA) web site:

The term nucleosynthesis refers to the formation of heavier elements, atomic nuclei with many protons and neutrons, from the fusion of lighter elements. The Big Bang theory predicts that the early universe was a very hot place. One second after the Big Bang, the temperature of the universe was roughly 10 billion degrees and was filled with a sea of neutrons, protons, electrons, anti-electrons (positrons), photons and neutrinos. As the universe cooled, the neutrons either decayed into protons and electrons or combined with protons to make deuterium (an isotope of hydrogen). During the first three minutes of the universe, most of the deuterium combined to make helium. Trace amounts of lithium were also produced at this time. This process of light element formation in the early universe is called “Big Bang nucleosynthesis” (BBN).

The creation hypothesis predicts that there will be specific amounts of these light elements formed as the universe cools down. Do the predictions match with observations?

Yes they do:

The predicted abundance of deuterium, helium and lithium depends on the density of ordinary matter in the early universe, as shown in the figure at left. These results indicate that the yield of helium is relatively insensitive to the abundance of ordinary matter, above a certain threshold. We generically expect about 24% of the ordinary matter in the universe to be helium produced in the Big Bang. This is in very good agreement with observations and is another major triumph for the Big Bang theory.

Moreover, WMAP satellite measurements of mass density agree with our observations of these light element abundances.

Here are the observations from the WMAP satellite:

Scientific observations match predictions
Scientific observations match predictions

And here is how those WMAP measurements confirm the Big Bang creation event:

However, the Big Bang model can be tested further. Given a precise measurement of the abundance of ordinary matter, the predicted abundances of the other light elements becomes highly constrained. The WMAP satellite is able to directly measure the ordinary matter density and finds a value of 4.6% (±0.2%), indicated by the vertical red line in the graph. This leads to predicted abundances shown by the circles in the graph, which are in good agreement with observed abundances. This is an important and detailed test of nucleosynthesis and is further evidence in support of the Big Bang theory. 

“An important and detailed test”.

For completeness, we should learn how elements heavier than these light elements are formed:

Elements heavier than lithium are all synthesized in stars. During the late stages of stellar evolution, massive stars burn helium to carbon, oxygen, silicon, sulfur, and iron. Elements heavier than iron are produced in two ways: in the outer envelopes of super-giant stars and in the explosion of a supernovae. All carbon-based life on Earth is literally composed of stardust.

That’s a wonderful thing to tell a young lady when you are on a date: “your body is made of stardust”. In fact, as I have argued before, this star formation, which creates the elements necessary for intelligent life, can only be built if the fundamental constants and quantities in the universe are finely-tuned.

Now, you would think that atheists would be happy to find observations that confirm the origin of the universe out of nothing, but they are not. Actually, they are in denial.

Here’s a statement from the Secular Humanist Manifesto, which explains what atheists believe about the universe:

Religious humanists regard the universe as self-existing and not created.

For a couple of examples of how atheistic scientists respond to the evidence for a cosmic beginning, you can check out this post, where we get responses from cosmologist Lawrence Krauss, and physical chemist Peter Atkins.

You cannot have the creation of the universe be true AND a self-existing, eternal universe ALSO be true. Someone has to be wrong. Either the science is wrong, or the atheist manifesto is wrong. I know where I stand.

Positive arguments for Christian theism