Tag Archives: Therapy

Adult stem cells therapy can fix a broken heart?

Mary sent me this article from the Irish Times.

Excerpt:

A new US study in which patients had their hearts repaired with stem cells has brought regenerative treatments for heart attacks a step closer.

The therapy, reported today in the Lancet  medical journal, halved the extent of normally permanent scarring on the heart, and led to the growth of new heart muscle.

However, the treatment produced no significant change in “ejection fraction” – a measure of the heart’s pumping capacity.

The Caduceus trial recruited a total of 25 patients with an average age of 53 who had all suffered a heart attack in the previous month.

Some 17 patients received coronary artery infusions of 12 to 25 million stem cells derived from healthy tissue taken from their own hearts. The remaining eight underwent standard post-heart attack care.

A year later, the proportion of the heart left scarred in the stem cell-treated patients had been reduced from 24 per cent to 12 per cent. No change was seen in patients who did not receive the treatment.

Professor Eduardo Marban, director of the Cedars-Sinai Heart Institute in Los Angeles, who led the US team, said: “The effects are substantial, and surprisingly larger in humans than they were in animal tests.

“This discovery challenges the conventional wisdom that, once established, scar is permanent and that, once lost, healthy heart muscle cannot be restored.”

The Phase I study, which was chiefly conducted to evaluate safety, was published today in an online edition of the Lancet.  It follows a similar trial by US scientists at Harvard Medical School and the University of Louisville whose findings were reported last year, also in the Lancet.

That study, which used a different kind of heart stem cell, produced a 12 per cent average increase in ejection fraction.

Yet another breakthrough for ethical adult stem cells.

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Read Theodore Dalrymple’s “Life at the Bottom” online for free

I want to recommend that you read a book that is available online for free.

The author  is a psychiatrist in a British hospital that deals with a lot of criminals and victims of crime. So he gets to see the worldview of the “underclass” up close, and to understand how the policies of the compassionate secular left are really working at the street level. The theme of the book is that the left advances policies in order to feel good about themselves, even though the policies actually hurt the poor and vulnerable far more than they help them. And the solution of the elites is more of the same.

The whole book is available ONLINE for free! From City Journal!

Table of Contents

The Knife Went In 5
Goodbye, Cruel World 15
Reader, She Married Him–Alas 26
Tough Love 36
It Hurts, Therefore I Am 48
Festivity, and Menace 58
We Don’t Want No Education 68
Uncouth Chic 78
The Heart of a Heartless World 89
There’s No Damned Merit in It 102
Choosing to Fail 114
Free to Choose 124
What Is Poverty? 134
Do Sties Make Pigs? 144
Lost in the Ghetto 155
And Dying Thus Around Us Every Day 167
The Rush from Judgment 181
What Causes Crime? 195
How Criminologists Foster Crime 208
Policemen in Wonderland 221
Zero Intolerance 233
Seeing Is Not Believing 244

Lots more essays are here, all from City Journal.

My favorite passage

The only bad thing about reading it online is that you miss one of the best quotes from the introduction. But I’ll type it out for you.

The disastrous pattern of human relationships that exists in the underclass is also becoming common higher up the social scale. With increasing frequency I am consulted by nurses, who for the most part come from and were themselves traditionally members of (at least after Florence Nightingale) the respectable lower middle class, who have illegitimate children by men who first abuse and then abandon them. This abuse and later abandonment is usually all too predictable from the man’s previous history and character; but the nurses who have been treated in this way say they refrained from making a judgment about him because it is wrong to make judgments. But if they do not make a judgment about the man with whom they are going to live and by whom they are going to have a child, about what are they ever going to make a judgment?

“It just didn’t work out,” they say, the “it” in question being the relationship that they conceive of having an existence independent of the two people who form it, and that exerts an influence on their on their lives rather like an astral projection. Life is fate.

This is something I run into myself. I think that young people today prefer moral relativists as mates, because they are afraid of being judged and rejected by people who are too serious about religion and morality. The problem is that if you choose someone who doesn’t take religion and morality seriously, then you can’t rely on them to behave morally and exercise spiritual leadership when raising children. And being sexually involved with someone who doesn’t take morality seriously causes a lot of damage.

An excerpt

Here’s one of my favorite passages from “Tough Love”, in which he describes how easily he can detect whether a particular man has violent tendencies on sight, whereas female victims of domestic violence – and even the hospital nurses – will not recognize the same signs.

All the more surprising is it to me, therefore, that the nurses perceive things differently. They do not see a man’s violence in his face, his gestures, his deportment, and his bodily adornments, even though they have the same experience of the patients as I. They hear the same stories, they see the same signs, but they do not make the same judgments. What’s more, they seem never to learn; for experience—like chance, in the famous dictum of Louis Pasteur—favors only the mind prepared. And when I guess at a glance that a man is an inveterate wife beater (I use the term “wife” loosely), they are appalled at the harshness of my judgment, even when it proves right once more.

This is not a matter of merely theoretical interest to the nurses, for many of them in their private lives have themselves been the compliant victims of violent men. For example, the lover of one of the senior nurses, an attractive and lively young woman, recently held her at gunpoint and threatened her with death, after having repeatedly blacked her eye during the previous months. I met him once when he came looking for her in the hospital: he was just the kind of ferocious young egotist to whom I would give a wide berth in the broadest daylight.

Why are the nurses so reluctant to come to the most inescapable of conclusions? Their training tells them, quite rightly, that it is their duty to care for everyone without regard for personal merit or deserts; but for them, there is no difference between suspending judgment for certain restricted purposes and making no judgment at all in any circumstances whatsoever. It is as if they were more afraid of passing an adverse verdict on someone than of getting a punch in the face—a likely enough consequence, incidentally, of their failure of discernment. Since it is scarcely possible to recognize a wife beater without inwardly condemning him, it is safer not to recognize him as one in the first place.

This failure of recognition is almost universal among my violently abused women patients, but its function for them is somewhat different from what it is for the nurses. The nurses need to retain a certain positive regard for their patients in order to do their job. But for the abused women, the failure to perceive in advance the violence of their chosen men serves to absolve them of all responsibility for whatever happens thereafter, allowing them to think of themselves as victims alone rather than the victims and accomplices they are. Moreover, it licenses them to obey their impulses and whims, allowing them to suppose that sexual attractiveness is the measure of all things and that prudence in the selection of a male companion is neither possible nor desirable.

Often, their imprudence would be laughable, were it not tragic: many times in my ward I’ve watched liaisons form between an abused female patient and an abusing male patient within half an hour of their striking up an acquaintance. By now, I can often predict the formation of such a liaison—and predict that it will as certainly end in violence as that the sun will rise tomorrow.

At first, of course, my female patients deny that the violence of their men was foreseeable. But when I ask them whether they think I would have recognized it in advance, the great majority—nine out of ten—reply, yes, of course. And when asked how they think I would have done so, they enumerate precisely the factors that would have led me to that conclusion. So their blindness is willful.

Go read the rest!

Book reviews

Liberal media silent as ESCR pioneer Geron halts ESCR research

Here’s the story from CBS News.

Excerpt:

The company doing the first government-approved test of embryonic stem cell therapy is discontinuing further stem cell work, a move with stark implications for a field offering hope of future medicines for conditions with inadequate or no current treatments.

Geron Corp., a pioneer in stem cell research that has been testing a spinal cord injury treatment, said late Monday that it’s halting development of its stem cell programs to conserve funds. It is seeking partners to take on the programs’ assets and is laying off much of its staff.

[…]The company is eliminating 66 full-time jobs, or 38 percent of its staff, a process that will bring about $8 million in costs— about $5 million in the current quarter and about $3 million in the first half of 2012.

Now consider this article in the Weekly Standard by Wesley J. Smith. (H/T ECM)

Excerpt:

For years, the media touted the promise of embryonic stem cells. Year after year, Geron Corporation announced that its embryonic stem cell treatment for acute spinal cord injury would receive FDA approval “next year” for human testing. And year after year, the media dutifully informed readers and viewers that cures were imminent. When the FDA finally did approve a tiny human trial for 10 patients in January 2009, the news exploded around the world. This was it: The era of embryonic stem cell therapy had arrived!

Not exactly. Last week, Geron issued a terse statement announcing it was not only canceling the study, but abandoning the embryonic stem cell field altogether for financial reasons.

You would think Geron’s failure would be very big news. Instead, it turns out that the mainstream media pay attention only when embryonic stem cell research seems to be succeeding—so far, almost exclusively in animal studies. When, as here, it crashes and burns, it is scarcely news at all.

[M]ost of the same news outlets that gave Geron star treatment when it was heralding supposed breakthroughs provided only muted coverage of the company’s retreat into producing anti-cancer drugs.

The Los Angeles Times may be the most egregious offender. A chronic booster of Geron’s embryonic stem cell research, it reported the FDA’s approval of a human trial on January 24, 2009, in a story that began, “Ushering in a new era in medicine .  .  . ” The paper stayed on the story. In October 2010, it reported that the first patient had received an injection, then a few days later it ran a feature about the study under the headline “Hope for Spinal Cord Patients.” During the same period, however, the paper did not report the encouraging results of early human trials of treatments for spinal cord injury developed using adult stem cells.

Then last May, the Times celebrated the California Institute of Regenerative Medicine’s $25 million loan to support Geron’s study, noting that the company’s stem cell product had performed as hoped in rat -studies. Yet the day after Geron’s embryonic stem cell research unit was laid off, the Times couldn’t find the space to print the story, though the following day a blog entry ran on the Times website.

The vast majority (all?) of medical successes with stem cell research have come from ethical adult stem-cell research. Adult stem cell research does not kill unborn children. And that’s why it doesn’t draw funding from pro-abortion politicians or get positive coverage by pro-abortion media outlets. The politics is driving the science – just like with global warming research and alternative energy funding.

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