Tag Archives: Enzyme

Walter Bradley: three scientific evidences that point to a designed universe

Dr. Walter L. Bradley
Dr. Walter L. Bradley

Dr. Walter L. Bradley (C.V. here) is the Distinguished Professor of Engineering at Baylor.

Here’s a bio:

Walter Bradley (B.S., Ph.D. University of Texas at Austin) is Distinguished Professor of Engineering at Baylor. He comes to Baylor from Texas A&M University where he helped develop a nationally recognized program in polymeric composite materials. At Texas A&M, he served as director of the Polymer Technology Center for 10 years and as Department Head of Mechanical Engineering, a department of 67 professors that was ranked as high as 12th nationally during his tenure. Bradley has authored over 150 refereed research publications including book chapters, articles in archival journals such as the Journal of Material Science, Journal of Reinforced Plastics and Composites, Mechanics of Time-Dependent Materials, Journal of Composites Technology and Research, Composite Science and Technology, Journal of Metals, Polymer Engineering and Science, and Journal of Materials Science, and refereed conference proceedings.

Dr. Bradley has secured over $5.0 million in research funding from NSF grants (15 yrs.), AFOSR (10 years), NASA grants (10 years), and DOE (3 years). He has also received research grants or contracts from many Fortune 500 companies, including Alcoa, Dow Chemical, DuPont, 3M, Shell, Exxon, Boeing, and Phillips.

He co-authored The Mystery of Life Origin: Reassessing Current Theories and has written 10 book chapters dealing with various faith science issues, a topic on which he speaks widely.

He has received 5 research awards at Texas A&M University and 1 national research award. He has also received two teaching awards. He is an Elected Fellow of the American Society for Materials and the American Scientific Affiliation (ASA), the largest organization of Christians in Science and Technology in the world. He is President elect of the ASA and will serve his term in 2008.

You can read more about his recent research in this article from Science Daily.

Below, I analyze a lecture entitled “Is There Scientific Evidence for an Intelligent Designer?”. Dr. Bradley explains how the progress of science has made the idea of a Creator and Designer of the universe more acceptable than ever before.

The MP3 file is here.

Evidence #1: The design of the universe

1. The correspondence of natural phenomena to mathematical law

  • All observations of physical phenomena in the universe, such as throwing a ball up in the air, are described by a few simple, elegant mathematical equations.

2. The fine-tuning of physical constants and rations between constants in order to provide a life-permitting universe

  • Life has certain minimal requirements; long-term stable source of energy, a large number of different chemical elements, an element that can serve as a hub for joining together other elements into compounds, etc.
  • In order to meet these minimal requirements, the physical constants, (such as the gravitational constant), and the ratios between physical constants, need to be withing a narrow range of values in order to support the minimal requirements for life of any kind.
  • Slight changes to any of the physical constants, or to the rations between the constants, will result in a universe inhospitable to life.
  • The range of possible ranges over 70 orders of magnitude.
  • Although each individual selection of constants and ratios is as unlikely as any other selection, the vast majority of these possibilities do not support the minimal requirements of life of any kind. (In the same way as any hand of 5 cards that is dealt is as likely as any other, but you are overwhelmingly likely NOT to get a royal flush. In our case, a royal flush is a life-permitting universe).

Examples of finely-tuned constants and ratios: (there are more examples in the lecture)

a) The strong force: (the force that binds nucleons (= protons and neutrons) together in nucleus, by means of meson exchange)

  • if the strong force constant were 2% stronger, there would be no stable hydrogen, no long-lived stars, no hydrogen containing compounds. This is because the single proton in hydrogen would want to stick to something else so badly that there would be no hydrogen left!
  • if the strong force constant were 5% weaker, there would be no stable stars, few (if any) elements besides hydrogen. This is because you would NOT be able to build up the nuclei of the heavier elements, which contain more than 1 proton.
  • So, whether you adjust the strong force up or down, you lose stars than can serve as long-term sources of stable energy, or you lose chemical diversity, which is necessary to make beings that can perform the minimal requirements of living beings. (see below)

b) The conversion of beryllium to carbon, and carbon to oxygen

  • Life requires carbon in order to serve as the hub for complex molecules, but it also requires oxygen in order to create water.
  • Carbon is like the hub wheel in a tinker toy set: you can bind other elements together to more complicated molecules (e.g. – “carbon-based life), but the bonds are not so tight that they can’t be broken down again later to make something else.
  • The carbon resonance level is determined by two constants: the strong force and electromagnetic force.
  • If you mess with these forces even slightly, you either lose the carbon or the oxygen.

3. Fine-tuning to allow a habitable planet

  • A number of factors must be fine-tuned in order to have a planet that supports life
  • Initial estimates predicted abundant life in the universe, but revised estimates now predict that life is almost certainly unique in the galaxy, and probably unique in the universe.
  • Even though there are lots of stars in the universe, the odds are against any of them supporting complex life.
  • Here are just a few of the minimal requirements for habitability: must be a single star solar system, in order to support stable planetary orbits, the planet must be the right distance from the sun in order to have liquid water at the surface, the planet must sufficient mass in order to retain an atmosphere, etc.

The best non-theistic response to this argument is to postulate a multiverse, but that is very speculative and there is no experimental evidence that supports it.

Evidence #2: The origin of the universe

1. The progress of science has shown that the entire physical universe came into being out of nothing (= “the big bang”). It also shows that the cause of this creation event is non-physical and non-temporal. The cause is supernatural.

  • Atheism prefers an eternal universe, to get around the problem of a Creator having to create the universe.
  • Discovery #1: Observations of galaxies moving away from one another confirms that the universe expanded from a single point.
  • Discovery #2: Measurements of the cosmic background radiation confirms that the universe exploding into being.
  • Discovery #3: Predictions of elemental abundances prove that the universe is not eternal.
  • Discovery #4:The atheism-friendly steady-state model and oscillating model were both falsified by the evidence.
  • And there were other discoveries as well, mentioned in the lecture.

The best non-theistic response to this argument is to postulate a hyper-universe outside of ours, but that is very speculative and there is no experimental evidence that supports it.

Evidence #3: The origin of life

1. The progress of science has shown that the simplest living organism contains huge amounts of biological information, similar to the Java code I write all day at work. This is a problem for atheists, because the sequence of instructions in a living system has to come together all at once, it cannot have evolved by mutation and selection – because there was no replication in place prior to the formation of that first living system!

  • Living systems must support certain minimum life functions: processing energy, storing information, and replicating.
  • There needs to be a certain amount of complexity in the living system that can perform these minimum functions.
  • But on atheism, the living system needs to be simple enough to form by accident in a pre-biotic soup, and in a reasonable amount of time.
  • The minimal functionality in a living system is a achieved by DNA, RNA and enzymes. DNA and RNA are composed of sequences of proteins, which are in turn composed of sequences of amino acids.

Consider the problems of building a chain of 100 amino acids

  • The amino acids must be left-handed only, but left and right kinds are equally abundant in nature. How do you sort out the right-handed ones?
  • The amino acids must be bound together using peptide bonds. How do you prevent other types of bonds?
  • Each link of the amino acid chain needs to be carefully chosen such that the completed chain with fold up into a protein. How do you choose the correct amino acid for each link from the pool of 20 different kinds found in living systems?
  • In every case, a human or other intelligence could solve these problems by doing what intelligent agents do best: making choices.
  • But who is there to make the choices on atheism?

The best current non-theistic response to this is to speculate that aliens may have seeded the Earth with life at some point in the past.

The problem of the origin of life is not a problem of chemistry, it is a problem of engineering. Every part of car functionality can be understood and described using the laws of physics and chemistry. But an intelligence is still needed in order to assemble the components into a system that has the minimal requirements for a functioning vehicle.

New study: enzymes cannot easily evolve to perform other functions

Can atheism explain the origin of life?
Can atheism explain the origin of life?

This is from Evolution News.

Excerpt:

I am pleased to announce the publication of a new paper from Biologic Institute, a research organization devoted to investigating the limits of unguided evolution and advancing the development of a new paradigm for biology based on intelligent design. This paper, “Enzyme Families — Shared Evolutionary History or Shared Design? A Study of the GABA-Aminotransferase Family,” is the closing chapter of our long-term study of bacterial enzymes to determine if they can be coopted to new functions. The answer to this question is important for the evolution debate. If enzymes can’t be recruited to genuinely new functions by unguided means, no matter how similar they are, the evolutionary story is false.

Published in the journal BIO-Complexity, the work was done by Marci Reeves, Doug Axe, and myself [Ann Gauger].

In a previous paper we described the difficulty of coopting the enzyme Kbl to perform the function of BioF. The two enzymes are very similar in structure (see below) but have different reaction chemistries and different functions in the cell. We wanted to know if a mutated Kbl could replace missing BioF function. After changing nearly every amino acid in Kbl’s active site (where its chemistry is carried out) to look like BioF, Kbl never was able to make the switch to BioF’s function.

In this paper we expanded the story to include nine of the most closely related enzymes to BioF, including one that is supposed to be able to carry out both BioF’s and Kbl’s chemistry. Using random mutagenesis we tested every single-base mutation in those nine genes. None of them was within one mutation of cooption. We went on to test for cooption the two most likely enzymes by generating two-base combinations of mutations. After testing 70 percent of all possible two-base mutations for each enzyme, or about 40 million cells each, that also failed.

What does this mean? In an evolutionary scenario, to get an enzyme to switch functions the first step is to make a spare copy that can be mutated without destroying a function the cell needs. Second, the cell has to overproduce the mutating enzyme, because any newly emerging enzyme will be very bad at the job at first. To compensate there will need to be lots of enzyme around. Third, there is the problem of finding the right combination of mutations by random search.

Taken together, since we found no enzyme that was within one mutation of cooption, the total number of mutations needed is at least four: one for duplication, one for over-production, and two or more single base changes. The waiting time required to achieve four mutations is 1015 years. That’s longer than the age of the universe. The real waiting time is likely to be much greater, since the two most likely candidate enzymes failed to be coopted by double mutations.

Read the rest of the post, they deal with criticisms to the paper.

Here is one Darwinist’s view of this enzyme proble, which they mention in a follow-up post.

Look: (links removed)

Monday we published a paper in the journal BIO-Complexity demonstrating that enzymes can’t evolve genuinely new functions by unguided means. We argue that design by a very sophisticated intelligent agent is the best explanation for their origin. I want to take some time to lay out our argument against Darwinian evolution and for intelligent design. It’s important, because it reveals the logical fallacy in most evolutionary thinking.

Just to give an example of the thinking of ID critics, here is a passage from one of the references in our paper (Kherhonsky et al. (2006) Enzyme promiscuity: Evolutionary and mechanistic aspects.Current Opinion in Chemical Biology 10:498-508):

An oft-forgotten essence of Darwinian processes is that they occur gradually, while maintaining organism fitness throughout. Consequently, a reasonable assumption is that, ever since the emergence of the primordial living forms, very little novelty has evolved at the molecular level. Rather, existing genes were modified, or tinkered with’, to generate new protein structures and functions that are related to those of their ancestors. Unlike ‘out of the blue’ scenarios advocated by the ‘intelligent design’ school, ‘tinkering’ scenarios depend on the availability of evolutionary starting points. The hypothesis that the broad specificity, or promiscuous functions, of existing enzymes provide these starting points was first formalized by Jensen in a review that has inspired many. Jensen proposed that, in contrast to modern enzymes, primitive enzymes possessed very broad specificities. This catalytic versatility enabled fewer enzymes to perform the multitude of functions that was necessary to maintain ancestral organisms. Duplication of genes and divergence led to specialized genes and increased metabolic efficiency. Since Jensen, the structures of >30,000 proteins, and the sequences of hundreds of thousands, have taught us that these processes led to the creation of enzyme families and superfamilies. The vestiges of these divergence processes are the scaffold and active site architecture shared by all family members [6].

To summarize, the key points of that evolutionary argument are:

  1. Evolution is true. That is, enzymes have evolved new functions by a process of random mutation and natural selection.
  2. Modern enzymes can’t evolve genuinely new functions by random mutation and natural selection but can only tinker with existing functions.
  3. Therefore, ancient enzymes must have been different, capable of carrying out a broad range of enzyme activities.
  4. Those enzymes underwent duplication and diverged from one another, becoming specialized.
  5. How do we know this happened? Because we now see a broad array of specialized enzymes. Evolution is the explanation.

This begs the question of whether evolution is true. It is a circular argument unsubstantiated by the evidence and unfalsifiable. No one can know what ancient enzymes actually looked like, and whether they really had such broad catalytic specificities.

That’s insufferable badness.

It’s not enough for Darwinists to take the age of the universe and then assert that anything can happen in that time. The time from the cooling of the Earth to the appearance of first life is on the order of millions of years. There just isn’t time to generate these organic components by chance.

Walter Bradley: three scientific evidences that point to a designed universe

Dr. Walter L. Bradley
Dr. Walter L. Bradley

Dr. Walter L. Bradley (C.V. here) is the Distinguished Professor of Engineering at Baylor.

Here’s a bio:

Walter Bradley (B.S., Ph.D. University of Texas at Austin) is Distinguished Professor of Engineering at Baylor. He comes to Baylor from Texas A&M University where he helped develop a nationally recognized program in polymeric composite materials. At Texas A&M, he served as director of the Polymer Technology Center for 10 years and as Department Head of Mechanical Engineering, a department of 67 professors that was ranked as high as 12th nationally during his tenure. Bradley has authored over 150 refereed research publications including book chapters, articles in archival journals such as the Journal of Material Science, Journal of Reinforced Plastics and Composites, Mechanics of Time-Dependent Materials, Journal of Composites Technology and Research, Composite Science and Technology, Journal of Metals, Polymer Engineering and Science, and Journal of Materials Science, and refereed conference proceedings.

Dr. Bradley has secured over $5.0 million in research funding from NSF grants (15 yrs.), AFOSR (10 years), NASA grants (10 years), and DOE (3 years). He has also received research grants or contracts from many Fortune 500 companies, including Alcoa, Dow Chemical, DuPont, 3M, Shell, Exxon, Boeing, and Phillips.

He co-authored The Mystery of Life Origin: Reassessing Current Theories and has written 10 book chapters dealing with various faith science issues, a topic on which he speaks widely.

He has received 5 research awards at Texas A&M University and 1 national research award. He has also received two teaching awards. He is an Elected Fellow of the American Society for Materials and the American Scientific Affiliation (ASA), the largest organization of Christians in Science and Technology in the world. He is President elect of the ASA and will serve his term in 2008.

You can read more about his recent research in this article from Science Daily.

Below, I analyze a lecture entitled “Is There Scientific Evidence for an Intelligent Designer?”. Dr. Bradley explains how the progress of science has made the idea of a Creator and Designer of the universe more acceptable than ever before.

The MP3 file is here.

Evidence #1: The design of the universe

1. The correspondence of natural phenomena to mathematical law

  • All observations of physical phenomena in the universe, such as throwing a ball up in the air, are described by a few simple, elegant mathematical equations.

2. The fine-tuning of physical constants and rations between constants in order to provide a life-permitting universe

  • Life has certain minimal requirements; long-term stable source of energy, a large number of different chemical elements, an element that can serve as a hub for joining together other elements into compounds, etc.
  • In order to meet these minimal requirements, the physical constants, (such as the gravitational constant), and the ratios between physical constants, need to be withing a narrow range of values in order to support the minimal requirements for life of any kind.
  • Slight changes to any of the physical constants, or to the rations between the constants, will result in a universe inhospitable to life.
  • The range of possible ranges over 70 orders of magnitude.
  • Although each individual selection of constants and ratios is as unlikely as any other selection, the vast majority of these possibilities do not support the minimal requirements of life of any kind. (In the same way as any hand of 5 cards that is dealt is as likely as any other, but you are overwhelmingly likely NOT to get a royal flush. In our case, a royal flush is a life-permitting universe).

Examples of finely-tuned constants and ratios: (there are more examples in the lecture)

a) The strong force: (the force that binds nucleons (= protons and neutrons) together in nucleus, by means of meson exchange)

  • if the strong force constant were 2% stronger, there would be no stable hydrogen, no long-lived stars, no hydrogen containing compounds. This is because the single proton in hydrogen would want to stick to something else so badly that there would be no hydrogen left!
  • if the strong force constant were 5% weaker, there would be no stable stars, few (if any) elements besides hydrogen. This is because you would NOT be able to build up the nuclei of the heavier elements, which contain more than 1 proton.
  • So, whether you adjust the strong force up or down, you lose stars than can serve as long-term sources of stable energy, or you lose chemical diversity, which is necessary to make beings that can perform the minimal requirements of living beings. (see below)

b) The conversion of beryllium to carbon, and carbon to oxygen

  • Life requires carbon in order to serve as the hub for complex molecules, but it also requires oxygen in order to create water.
  • Carbon is like the hub wheel in a tinker toy set: you can bind other elements together to more complicated molecules (e.g. – “carbon-based life), but the bonds are not so tight that they can’t be broken down again later to make something else.
  • The carbon resonance level is determined by two constants: the strong force and electromagnetic force.
  • If you mess with these forces even slightly, you either lose the carbon or the oxygen.

3. Fine-tuning to allow a habitable planet

  • A number of factors must be fine-tuned in order to have a planet that supports life
  • Initial estimates predicted abundant life in the universe, but revised estimates now predict that life is almost certainly unique in the galaxy, and probably unique in the universe.
  • Even though there are lots of stars in the universe, the odds are against any of them supporting complex life.
  • Here are just a few of the minimal requirements for habitability: must be a single star solar system, in order to support stable planetary orbits, the planet must be the right distance from the sun in order to have liquid water at the surface, the planet must sufficient mass in order to retain an atmosphere, etc.

The best non-theistic response to this argument is to postulate a multiverse, but that is very speculative and there is no experimental evidence that supports it.

Evidence #2: The origin of the universe

1. The progress of science has shown that the entire physical universe came into being out of nothing (= “the big bang”). It also shows that the cause of this creation event is non-physical and non-temporal. The cause is supernatural.

  • Atheism prefers an eternal universe, to get around the problem of a Creator having to create the universe.
  • Discovery #1: Observations of galaxies moving away from one another confirms that the universe expanded from a single point.
  • Discovery #2: Measurements of the cosmic background radiation confirms that the universe exploding into being.
  • Discovery #3: Predictions of elemental abundances prove that the universe is not eternal.
  • Discovery #4:The atheism-friendly steady-state model and oscillating model were both falsified by the evidence.
  • And there were other discoveries as well, mentioned in the lecture.

The best non-theistic response to this argument is to postulate a hyper-universe outside of ours, but that is very speculative and there is no experimental evidence that supports it.

Evidence #3: The origin of life

1. The progress of science has shown that the simplest living organism contains huge amounts of biological information, similar to the Java code I write all day at work. This is a problem for atheists, because the sequence of instructions in a living system has to come together all at once, it cannot have evolved by mutation and selection – because there was no replication in place prior to the formation of that first living system!

  • Living systems must support certain minimum life functions: processing energy, storing information, and replicating.
  • There needs to be a certain amount of complexity in the living system that can perform these minimum functions.
  • But on atheism, the living system needs to be simple enough to form by accident in a pre-biotic soup, and in a reasonable amount of time.
  • The minimal functionality in a living system is a achieved by DNA, RNA and enzymes. DNA and RNA are composed of sequences of proteins, which are in turn composed of sequences of amino acids.

Consider the problems of building a chain of 100 amino acids

  • The amino acids must be left-handed only, but left and right kinds are equally abundant in nature. How do you sort out the right-handed ones?
  • The amino acids must be bound together using peptide bonds. How do you prevent other types of bonds?
  • Each link of the amino acid chain needs to be carefully chosen such that the completed chain with fold up into a protein. How do you choose the correct amino acid for each link from the pool of 20 different kinds found in living systems?
  • In every case, a human or other intelligence could solve these problems by doing what intelligent agents do best: making choices.
  • But who is there to make the choices on atheism?

The best current non-theistic response to this is to speculate that aliens may have seeded the Earth with life at some point in the past.

The problem of the origin of life is not a problem of chemistry, it is a problem of engineering. Every part of car functionality can be understood and described using the laws of physics and chemistry. But an intelligence is still needed in order to assemble the components into a system that has the minimal requirements for a functioning vehicle.