Adult stem cells therapy can fix a broken heart?

Mary sent me this article from the Irish Times.

Excerpt:

A new US study in which patients had their hearts repaired with stem cells has brought regenerative treatments for heart attacks a step closer.

The therapy, reported today in the Lancet  medical journal, halved the extent of normally permanent scarring on the heart, and led to the growth of new heart muscle.

However, the treatment produced no significant change in “ejection fraction” – a measure of the heart’s pumping capacity.

The Caduceus trial recruited a total of 25 patients with an average age of 53 who had all suffered a heart attack in the previous month.

Some 17 patients received coronary artery infusions of 12 to 25 million stem cells derived from healthy tissue taken from their own hearts. The remaining eight underwent standard post-heart attack care.

A year later, the proportion of the heart left scarred in the stem cell-treated patients had been reduced from 24 per cent to 12 per cent. No change was seen in patients who did not receive the treatment.

Professor Eduardo Marban, director of the Cedars-Sinai Heart Institute in Los Angeles, who led the US team, said: “The effects are substantial, and surprisingly larger in humans than they were in animal tests.

“This discovery challenges the conventional wisdom that, once established, scar is permanent and that, once lost, healthy heart muscle cannot be restored.”

The Phase I study, which was chiefly conducted to evaluate safety, was published today in an online edition of the Lancet.  It follows a similar trial by US scientists at Harvard Medical School and the University of Louisville whose findings were reported last year, also in the Lancet.

That study, which used a different kind of heart stem cell, produced a 12 per cent average increase in ejection fraction.

Yet another breakthrough for ethical adult stem cells.

Related posts

Rick Santorum, Mitt Romney and Newt Gingrich’s views on global warming

Rick Santorum does not accept global warming socialism

From WPXI News.

Excerpt:

About 500 people showed up Monday at a local diner in Steubenville, Ohio, to support former Pennsylvania Sen. Rick Santorum as he gave a policy speech.

Santorum said President Barack Obama is pushing a radical environmental agenda that unwisely limits energy production and turns its back on science.

Santorum told voters in Steubenville Monday that science is on the side of those who want to aggressively produce more oil and natural gas in America. He said the notion of global warming is not climate science, but “political science.”

Santorum said Obama and his allies want to frighten people about new oil-exploration technologies so they can get their dollars and turn them over to politicians to win elections “so they can control your lives.”

Here’s Santorum in his own words: “There is no such thing as global warming”

And more Santorum: Global warming is “junk science”

Santorum calls global warming a “hoax” and opposes cap and trade carbon taxes:

Do you think that Rick Santorum would build the Keystone XL pipeline and create the 20,000 jobs? YES HE WOULD.

Mitt Romney accepts global warming socialism

What about Mitt Romney’s view on global warming?

Excerpt:

On the environment, Romney seemed interested in carving out an agenda largely in line with the state’s most fervent activists on the left.

After he took office in 2003, some state employees and activists were nervous about how the new governor would approach the climate-change issue. Massachusetts had already reached an agreement with other Northeastern states and some Canadian provinces on a plan to limit greenhouse gas emissions.

Romney surprised them by taking a hands-on approach, personally helping craft a “Massachusetts Climate Protection Plan” that he unveiled in 2004.

He reorganized the state government to create the Office of Commonwealth Development — with the former president of the liberal Conservation Law Foundation, Douglas Foy, as its head — to better coordinate climate work and sustainable-growth activities among different agencies.

As he worked on the plan, according to people familiar with the process, he even overruled some objections by his chief of staff, who criticized the plan as potentially too left-leaning.

Romney backed incentives for buying efficient vehicles, tougher vehicle emissions rules and mandatory cuts in emissions linked to global warming.

The plan not only called for reducing the state’s overall greenhouse gas emissions to 1990 levels by 2010 and cutting them another 10 percent by 2020, but it said that “to eliminate any dangerous threat to the climate . . . current science suggests this will require reductions as much as 75-85 percent below current levels.”

[…]Beyond the state climate plan, Romney repeatedly pushed to promote clean energy and cut the use of fossil fuels.

In March 2003 he pledged to buy up to $100 million worth of electricity from renewable sources. That month, he declared, “the global warming debate is now pretty much over.”

Here’s Mitt Romney in his own words:

Do you think that Mitt Romney would create the Keystone XL pipeline and create the 20,000 jobs? I say NO HE WOULD NOT.

Newt Gingrich accepts global warming socialism

What about Newt Gingrich’s view on global warming?

Excerpt:

Republican presidential contender Newt Gingrich, as a U.S. House representative from Georgia in 1989, was among the co-sponsors of a sweeping global warming bill that, among other things, called for an international agreement on population growth.

[…]The… Global Warming Prevention Act of 1989 (H.R. 1078) had144 co-sponsors, the majority of which were liberal Democrats such as Rep. Nancy Pelosi (D-Calif.), then-Rep. Barbara Boxer (D-Calif.) and Rep. Barney Frank (D-Mass.) and Rep. John Conyers (D-Mich.). There were only 25 Republican co-sponsors, which included Rep. Gingrich.

The legislation… set a national goal of reducing carbon dioxide levels by at least 20 percent by the year 2000 “through a mix of federal and state energy policies,” as well as “the establishment of an International Global Agreement on the Atmosphere by 1992.”

In addition, the legislation’s summary includes the section “Title XI: World Population Growth.” That section states: “World Population Growth — Declares it is the policy of the United States that family planning services should be made available to all persons requesting them. Authorizes appropriations for FY 1991 through 1995 for international population and family planning assistance. Prohibits the use of such funds for: (1) involuntary sterilization or abortion; or (2) the coercion of any person to accept family planning services.

[…]In 2008, Gingrich appeared alongside Rep. Pelosi (D-Calif.) in a television ad calling for action to address the apparent global warming problem.

Here’s Newt Gingrich in his own words:

Do you think that Newt Gingrich would create the Keystone XL pipeline and create the 20,000 jobs? I say NO HE WOULD NOT.

Which one of these three candidates is the real conservative?

Rick Santorum

Mitt Romney

Another Life Training Institute podcast is here

Here’s the link.

Details:

Jay, Scott, and Rich are back to take on the most recent news in the bioethics community. This week we address the Obama administration’s mandate for religious organizations to include contraceptive and abortifacient coverage in their health insurance. Is this just a “Catholic Issue”, or is there significant ramifications for those of all faiths.

The MP3 file is here.

I really liked this one. It was just full of substance and boldness.