Tag Archives: Doug Axe

New software calculates the probability of generating functional proteins by chance

Apologetics and the progress of science
Apologetics and the progress of science

Here’s an article sent to me by JoeCoder about a new computer program written by Kirk Durston.

About Kirk:

Kirk Durston is a scientist, a philosopher, and a clergyman with a Ph.D. in Biophysics, an M.A. in Philosophy, a B.Sc. in Mechanical Engineering, and a B.Sc. in Physics. His work involves a significant amount of time thinking, writing and speaking about the interaction of science, theology and philosophy within the context of authentic Christianity. He has been married for 34 years to Patti and they have six children and three grandchildren. He enjoys landscape photography, antiques of various types, wilderness canoeing and camping, fly fishing, amateur astronomy, reading, music, playing the saxophone (alto), and enjoying family and friends.

Kirk grew up on a cattle and grain farm in central Manitoba, Canada, where he spent countless hours wandering around on his own in the forest as a young boy, fascinated with the plants and animals that are native to that region of the province. Throughout his teen years he spent six days a week in the summer working as a farm hand with cattle and grain. He left his father’s farm at the age of 19 to go to university.

Canada? Can anything good come out of Canada? Oh well, at least he’s not from Scotland. Anyway, on to the research, that’s what we care about. Code!

Summary of the article:

  • Biological life requires proteins
  • Proteins are sequences of amino acids, chained together
  • the order of amino acids determines whether the sequence has biological function
  • sequences that have biological function are rare, compared to the total number of possible sequences
  • Durston wrote a program to calculate the number of the probability of getting a functional sequence by random chance
  • The probability for getting a functional protein by chance is incredibly low

With that said, we can understand what he wrote:

This program can compute an upper limit for the probability of obtaining a protein family from a wealth of actual data contained in the Pfam database. The first step computes the lower limit for the functional complexity or functional information required to code for a particular protein family, using a method published by Durston et al. This value for I(Ex) can then be plugged into an equation published by Hazen et al. in order to solve the probability M(Ex)/N of ‘finding’ a functional sequence in a single trial.

I downloaded 3,751 aligned sequences for the Ribosomal S7 domain, part of a universal protein essential for all life. When the data was run through the program, it revealed that the lower limit for the amount of functional information required to code for this domain is 332 Fits (Functional Bits). The extreme upper limit for the number of sequences that might be functional for this domain is around 10^92. In a single trial, the probability of obtaining a sequence that would be functional for the Ribosomal S7 domain is 1 chance in 10^100 … and this is only for a 148 amino acid structural domain, much smaller than an average protein.

For another example, I downloaded 4,986 aligned sequences for the ABC-3 family of proteins and ran it through the program. The results indicate that the probability of obtaining, in a single trial, a functional ABC-3 sequence is around 1 chance in 10^128. This method ignores pairwise and higher order relationships within the sequence that would vastly limit the number of functional sequences by many orders of magnitude, reducing the probability even further by many orders of magnitude – so this gives us a best-case estimate.

There are only about 10^80 particles in the entire physical universe – 10^85 at the most. These are long odds. But maybe if we expand the probabilistic resources by buying more slot machines, and we pull the slot machine lever at much faster rate… can we win the jackpot then?

Nope:

What are the implications of these results, obtained from actual data, for the fundamental prediction of neo-Darwinian theory mentioned above? If we assume 10^30 life forms with a fast replication rate of 30 minutes and a huge genome with a very high mutation rate over a period of 10 billion years, an extreme upper limit for the total number of mutations for all of life’s history would be around 10^43. Unfortunately, a protein domain such as Ribosomal S7 would require a minimum average of 10^100 trials, about 10^57 trials more than the entire theoretical history of life could provide – and this is only for one domain. Forget about ‘finding’ an average sized protein, not to mention thousands.

So even if you have lots of probabilistic resources, and lots of time, you’re still not going to get your protein.

Compare these numbers with the 1 in 10^77 number that I posted about yesterday from Doug Axe. There is just no way to account for proteins if there is no intelligent agent to place the amino acids in sequence. When it comes to writing code, writing blog posts, writing music, or placing Scrabble letters, you need an intelligence. Sequencing amino acids into proteins? You need an intelligence.

Walter Bradley: three scientific evidences that point to a designed universe

Dr. Walter L. Bradley
Dr. Walter L. Bradley

Dr. Walter L. Bradley (C.V. here) is the Distinguished Professor of Engineering at Baylor.

Here’s a bio:

Walter Bradley (B.S., Ph.D. University of Texas at Austin) is Distinguished Professor of Engineering at Baylor. He comes to Baylor from Texas A&M University where he helped develop a nationally recognized program in polymeric composite materials. At Texas A&M, he served as director of the Polymer Technology Center for 10 years and as Department Head of Mechanical Engineering, a department of 67 professors that was ranked as high as 12th nationally during his tenure. Bradley has authored over 150 refereed research publications including book chapters, articles in archival journals such as the Journal of Material Science, Journal of Reinforced Plastics and Composites, Mechanics of Time-Dependent Materials, Journal of Composites Technology and Research, Composite Science and Technology, Journal of Metals, Polymer Engineering and Science, and Journal of Materials Science, and refereed conference proceedings.

Dr. Bradley has secured over $5.0 million in research funding from NSF grants (15 yrs.), AFOSR (10 years), NASA grants (10 years), and DOE (3 years). He has also received research grants or contracts from many Fortune 500 companies, including Alcoa, Dow Chemical, DuPont, 3M, Shell, Exxon, Boeing, and Phillips.

He co-authored The Mystery of Life Origin: Reassessing Current Theories and has written 10 book chapters dealing with various faith science issues, a topic on which he speaks widely.

He has received 5 research awards at Texas A&M University and 1 national research award. He has also received two teaching awards. He is an Elected Fellow of the American Society for Materials and the American Scientific Affiliation (ASA), the largest organization of Christians in Science and Technology in the world. He is President elect of the ASA and will serve his term in 2008.

You can read more about his recent research in this article from Science Daily.

Below, I analyze a lecture entitled “Is There Scientific Evidence for an Intelligent Designer?”. Dr. Bradley explains how the progress of science has made the idea of a Creator and Designer of the universe more acceptable than ever before.

The MP3 file is here.

Evidence #1: The design of the universe

1. The correspondence of natural phenomena to mathematical law

  • All observations of physical phenomena in the universe, such as throwing a ball up in the air, are described by a few simple, elegant mathematical equations.

2. The fine-tuning of physical constants and rations between constants in order to provide a life-permitting universe

  • Life has certain minimal requirements; long-term stable source of energy, a large number of different chemical elements, an element that can serve as a hub for joining together other elements into compounds, etc.
  • In order to meet these minimal requirements, the physical constants, (such as the gravitational constant), and the ratios between physical constants, need to be withing a narrow range of values in order to support the minimal requirements for life of any kind.
  • Slight changes to any of the physical constants, or to the rations between the constants, will result in a universe inhospitable to life.
  • The range of possible ranges over 70 orders of magnitude.
  • Although each individual selection of constants and ratios is as unlikely as any other selection, the vast majority of these possibilities do not support the minimal requirements of life of any kind. (In the same way as any hand of 5 cards that is dealt is as likely as any other, but you are overwhelmingly likely NOT to get a royal flush. In our case, a royal flush is a life-permitting universe).

Examples of finely-tuned constants and ratios: (there are more examples in the lecture)

a) The strong force: (the force that binds nucleons (= protons and neutrons) together in nucleus, by means of meson exchange)

  • if the strong force constant were 2% stronger, there would be no stable hydrogen, no long-lived stars, no hydrogen containing compounds. This is because the single proton in hydrogen would want to stick to something else so badly that there would be no hydrogen left!
  • if the strong force constant were 5% weaker, there would be no stable stars, few (if any) elements besides hydrogen. This is because you would NOT be able to build up the nuclei of the heavier elements, which contain more than 1 proton.
  • So, whether you adjust the strong force up or down, you lose stars than can serve as long-term sources of stable energy, or you lose chemical diversity, which is necessary to make beings that can perform the minimal requirements of living beings. (see below)

b) The conversion of beryllium to carbon, and carbon to oxygen

  • Life requires carbon in order to serve as the hub for complex molecules, but it also requires oxygen in order to create water.
  • Carbon is like the hub wheel in a tinker toy set: you can bind other elements together to more complicated molecules (e.g. – “carbon-based life), but the bonds are not so tight that they can’t be broken down again later to make something else.
  • The carbon resonance level is determined by two constants: the strong force and electromagnetic force.
  • If you mess with these forces even slightly, you either lose the carbon or the oxygen.

3. Fine-tuning to allow a habitable planet

  • A number of factors must be fine-tuned in order to have a planet that supports life
  • Initial estimates predicted abundant life in the universe, but revised estimates now predict that life is almost certainly unique in the galaxy, and probably unique in the universe.
  • Even though there are lots of stars in the universe, the odds are against any of them supporting complex life.
  • Here are just a few of the minimal requirements for habitability: must be a single star solar system, in order to support stable planetary orbits, the planet must be the right distance from the sun in order to have liquid water at the surface, the planet must sufficient mass in order to retain an atmosphere, etc.

The best non-theistic response to this argument is to postulate a multiverse, but that is very speculative and there is no experimental evidence that supports it.

Evidence #2: The origin of the universe

1. The progress of science has shown that the entire physical universe came into being out of nothing (= “the big bang”). It also shows that the cause of this creation event is non-physical and non-temporal. The cause is supernatural.

  • Atheism prefers an eternal universe, to get around the problem of a Creator having to create the universe.
  • Discovery #1: Observations of galaxies moving away from one another confirms that the universe expanded from a single point.
  • Discovery #2: Measurements of the cosmic background radiation confirms that the universe exploding into being.
  • Discovery #3: Predictions of elemental abundances prove that the universe is not eternal.
  • Discovery #4:The atheism-friendly steady-state model and oscillating model were both falsified by the evidence.
  • And there were other discoveries as well, mentioned in the lecture.

The best non-theistic response to this argument is to postulate a hyper-universe outside of ours, but that is very speculative and there is no experimental evidence that supports it.

Evidence #3: The origin of life

1. The progress of science has shown that the simplest living organism contains huge amounts of biological information, similar to the Java code I write all day at work. This is a problem for atheists, because the sequence of instructions in a living system has to come together all at once, it cannot have evolved by mutation and selection – because there was no replication in place prior to the formation of that first living system!

  • Living systems must support certain minimum life functions: processing energy, storing information, and replicating.
  • There needs to be a certain amount of complexity in the living system that can perform these minimum functions.
  • But on atheism, the living system needs to be simple enough to form by accident in a pre-biotic soup, and in a reasonable amount of time.
  • The minimal functionality in a living system is a achieved by DNA, RNA and enzymes. DNA and RNA are composed of sequences of proteins, which are in turn composed of sequences of amino acids.

Consider the problems of building a chain of 100 amino acids

  • The amino acids must be left-handed only, but left and right kinds are equally abundant in nature. How do you sort out the right-handed ones?
  • The amino acids must be bound together using peptide bonds. How do you prevent other types of bonds?
  • Each link of the amino acid chain needs to be carefully chosen such that the completed chain with fold up into a protein. How do you choose the correct amino acid for each link from the pool of 20 different kinds found in living systems?
  • In every case, a human or other intelligence could solve these problems by doing what intelligent agents do best: making choices.
  • But who is there to make the choices on atheism?

The best current non-theistic response to this is to speculate that aliens may have seeded the Earth with life at some point in the past.

The problem of the origin of life is not a problem of chemistry, it is a problem of engineering. Every part of car functionality can be understood and described using the laws of physics and chemistry. But an intelligence is still needed in order to assemble the components into a system that has the minimal requirements for a functioning vehicle.

Stephen C. Meyer lectures on intelligent design and the origin of life

A MUST-SEE lecture based on Dr. Stephen C. Meyer’s book “Signature in the Cell“.

You can get an MP3 of the lecture here. (30 MB)

I highly recommend watching the lecture, and looking at the slides. The quality of the video and the content is first class. There is some Q&A (9 minutes) at the end of the lecture.

Topics:

  • intelligent design is concerned with measuring the information-creating capabilities of natural forces like mutation and selection
  • Darwinists think that random mutations and natural selection can explain the origin and diversification of living systems
  • Darwinian mechanisms are capable of explaining small-scale adaptive changes within types of organisms
  • but there is skepticism, even among naturalists, that Darwinian mechanisms can explain the origin of animal designs
  • even if you concede that Darwinism can account for all of the basic animal body plans, there is still the problem of life’s origin
  • can Darwinian mechanisms explain the origin of the first life? Is there a good naturalistic hypothesis to explain it?
  • there are at least two places in the history of life where new information is needed: origin of life, and Cambrian explosion
  • overview of the structure of DNA and protein synthesis (he has helpful pictures and he uses the snap lock blocks, too)
  • the DNA molecule is composed of a sequence of proteins, and the sequence is carefully selected to have biological function
  • meaningful sequences of things like computer code, English sentences, etc. require an adequate cause
  • it is very hard to arrive at a meaningful sequence of a non-trivial length by randomly picking symbols/letters
  • although any random sequence of letters is improbable, the vast majority of sequences are gibberish/non-compiling code
  • similarly, most random sequences of amino acids are lab-proven (Doug Axe’s work) to be non-functional gibberish
  • the research showing this was conducted at Cambridge University and published in the Journal of Molecular Biology
  • so, random mutation cannot explain the origin of the first living cell
  • however, even natural selection coupled with random mutation cannot explain the first living cell
  • there must already be replication in order for mutation and selection to work, so they can’t explain the first replicator
  • but the origin of life is the origin of the first replicator – there is no replication prior to the first replicator
  • the information in the first replicator cannot be explained by law, such as by chemical bonding affinities
  • the amino acids are attached like magnetic letters on a refrigerator
  • the magnetic force sticks the letters ON the fridge, but they don’t determine the specific sequence of the letters
  • if laws did determine the sequence of letters, then the sequences would be repetitive
  • the three materialist explanations – chance alone, chance and law, law alone – are not adequate to explain the effect
  • the best explanation is that an intelligent cause is responsible for the biological explanation in the first replicator
  • we know that intelligent causes can produce functional sequences of information, e.g. – English, Java code
  • the structure and design of DNA matches up nicely with the design patterns used by software engineers (like WK!)

There are some very good tips in this lecture so that you will be able to explain intelligent design to others in simple ways, using everyday household items and children’s toys to symbolize the amino acids, proteins, sugar phosphate backbones, etc.

Proteins are constructed from a sequence of amino acids:

A sequence of amino acids forming a protein
A sequence of amino acids forming a protein

Proteins sticking onto the double helix structure of DNA:

Some proteins sticking onto the sugar phosphate backbone
Some proteins sticking onto the sugar phosphate backbone

I highly, highly recommend this lecture. You will be delighted and you will learn something.

Here is an article that gives a general overview of how intelligent design challenges. If you want to read something more detailed about the material that he is covering in the lecture above related to the origin of life, there is a pretty good article here.

UPDATE: There is a good breakdown of some of the slides with helpful flow charts here on Uncommon Descent.

Positive arguments for Christian theism

Stephen C. Meyer lectures on intelligent design and the origin of life

A MUST-SEE lecture based on Dr. Stephen C. Meyer’s book “Signature in the Cell“.

You can get an MP3 of the lecture here. (30 MB)

I highly recommend watching the lecture, and looking at the slides. The quality of the video and the content is first class. There is some Q&A (9 minutes) at the end of the lecture.

Topics:

  • intelligent design is concerned with measuring the information-creating capabilities of natural forces like mutation and selection
  • Darwinists think that random mutations and natural selection can explain the origin and diversification of living systems
  • Darwinian mechanisms are capable of explaining small-scale adaptive changes within types of organisms
  • but there is skepticism, even among naturalists, that Darwinian mechanisms can explain the origin of animal designs
  • even if you concede that Darwinism can account for all of the basic animal body plans, there is still the problem of life’s origin
  • can Darwinian mechanisms explain the origin of the first life? Is there a good naturalistic hypothesis to explain it?
  • there are at least two places in the history of life where new information is needed: origin of life, and Cambrian explosion
  • overview of the structure of DNA and protein synthesis (he has helpful pictures and he uses the snap lock blocks, too)
  • the DNA molecule is composed of a sequence of proteins, and the sequence is carefully selected to have biological function
  • meaningful sequences of things like computer code, English sentences, etc. require an adequate cause
  • it is very hard to arrive at a meaningful sequence of a non-trivial length by randomly picking symbols/letters
  • although any random sequence of letters is improbable, the vast majority of sequences are gibberish/non-compiling code
  • similarly, most random sequences of amino acids are lab-proven (Doug Axe’s work) to be non-functional gibberish
  • the research showing this was conducted at Cambridge University and published in the Journal of Molecular Biology
  • so, random mutation cannot explain the origin of the first living cell
  • however, even natural selection coupled with random mutation cannot explain the first living cell
  • there must already be replication in order for mutation and selection to work, so they can’t explain the first replicator
  • but the origin of life is the origin of the first replicator – there is no replication prior to the first replicator
  • the information in the first replicator cannot be explained by law, such as by chemical bonding affinities
  • the amino acids are attached like magnetic letters on a refrigerator
  • the magnetic force sticks the letters ON the fridge, but they don’t determine the specific sequence of the letters
  • if laws did determine the sequence of letters, then the sequences would be repetitive
  • the three materialist explanations – chance alone, chance and law, law alone – are not adequate to explain the effect
  • the best explanation is that an intelligent cause is responsible for the biological explanation in the first replicator
  • we know that intelligent causes can produce functional sequences of information, e.g. – English, Java code
  • the structure and design of DNA matches up nicely with the design patterns used by software engineers (like WK!)

There are some very good tips in this lecture so that you will be able to explain intelligent design to others in simple ways, using everyday household items and children’s toys to symbolize the amino acids, proteins, sugar phosphate backbones, etc.

Proteins are constructed from a sequence of amino acids:

A sequence of amino acids forming a protein
A sequence of amino acids forming a protein

Proteins sticking onto the double helix structure of DNA:

Some proteins sticking onto the sugar phosphate backbone
Some proteins sticking onto the sugar phosphate backbone

I highly, highly recommend this lecture. You will be delighted and you will learn something.

Here is an article that gives a general overview of how intelligent design challenges. If you want to read something more detailed about the material that he is covering in the lecture above related to the origin of life, there is a pretty good article here.

UPDATE: There is a good breakdown of some of the slides with helpful flow charts here on Uncommon Descent.

Positive arguments for Christian theism

Dr. Stephen C. Meyer lectures on intelligent design and the origin of life

A MUST-SEE lecture based on Dr. Stephen C. Meyer’s book “Signature in the Cell“.

You can get an MP3 of the lecture here. (30 MB)

I highly recommend watching the lecture, and looking at the slides. The quality of the video and the content is first class. There is some Q&A (9 minutes) at the end of the lecture.

Topics:

  • intelligent design is concerned with measuring the information-creating capabilities of natural forces like mutation and selection
  • Darwinists think that random mutations and natural selection can explain the origin and diversification of living systems
  • Darwinian mechanisms are capable of explaining small-scale adaptive changes within types of organisms
  • but there is skepticism, even among naturalists, that Darwinian mechanisms can explain the origin of animal designs
  • even if you concede that Darwinism can account for all of the basic animal body plans, there is still the problem of life’s origin
  • can Darwinian mechanisms explain the origin of the first life? Is there a good naturalistic hypothesis to explain it?
  • there are at least two places in the history of life where new information is needed: origin of life, and Cambrian explosion
  • overview of the structure of DNA and protein synthesis (he has helpful pictures and he uses the snap lock blocks, too)
  • the DNA molecule is composed of a sequence of proteins, and the sequence is carefully selected to have biological function
  • meaningful sequences of things like computer code, English sentences, etc. require an adequate cause
  • it is very hard to arrive at a meaningful sequence of a non-trivial length by randomly picking symbols/letters
  • although any random sequence of letters is improbable, the vast majority of sequences are gibberish/non-compiling code
  • similarly, most random sequences of amino acids are lab-proven (Doug Axe’s work) to be non-functional gibberish
  • the research showing this was conducted at Cambridge University and published in the Journal of Molecular Biology
  • so, random mutation cannot explain the origin of the first living cell
  • however, even natural selection coupled with random mutation cannot explain the first living cell
  • there must already be replication in order for mutation and selection to work, so they can’t explain the first replicator
  • but the origin of life is the origin of the first replicator – there is no replication prior to the first replicator
  • the information in the first replicator cannot be explained by law, such as by chemical bonding affinities
  • the amino acids are attached like magnetic letters on a refrigerator
  • the magnetic force sticks the letters ON the fridge, but they don’t determine the specific sequence of the letters
  • if laws did determine the sequence of letters, then the sequences would be repetitive
  • the three materialist explanations – chance alone, chance and law, law alone – are not adequate to explain the effect
  • the best explanation is that an intelligent cause is responsible for the biological explanation in the first replicator
  • we know that intelligent causes can produce functional sequences of information, e.g. – English, Java code
  • the structure and design of DNA matches up nicely with the design patterns used by software engineers (like WK!)

There are some very good tips in this lecture so that you will be able to explain intelligent design to others in simple ways, using everyday household items and children’s toys to symbolize the amino acids, proteins, sugar phosphate backbones, etc.

Proteins are constructed from a sequence of amino acids:

A sequence of amino acids forming a protein
A sequence of amino acids forming a protein

Proteins sticking onto the double helix structure of DNA:

Some proteins sticking onto the sugar phosphate backbone
Some proteins sticking onto the sugar phosphate backbone

I highly, highly recommend this lecture. You will be delighted and you will learn something.

Here is an article that gives a general overview of how intelligent design challenges. If you want to read something more detailed about the material that he is covering in the lecture above related to the origin of life, there is a pretty good article here.

UPDATE: There is a good breakdown of some of the slides with helpful flow charts here on Uncommon Descent.

Positive arguments for Christian theism